Synthesis of New Chiral [2-（1-Hydroxyalkyl）pyrrolidino]methylferrocenes and Application to the Catalytic Asymmetric Addition of Diethylzinc to Arylaldehydes  

作　　者：徐翠莲 王敏灿 侯学会 刘宏民 王德坤 

机构地区：[1]Department of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China

出　　处：《Chinese Journal of Chemistry》2005年第10期1443-1448,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20172047） and the Education Commission of Henan Province.

摘　　要：A series of new optically active [2-（1-hydroxyalkyl）pyrrolidino]methylferrocenes were conveniently prepared from commercially available L-proline and ferrocenecarboxylic acid. The crystal structure of key intermediate was obtained. They were then applied to catalyze enantioselective addition of diethylzinc to arylaldehydes with enantioselectivity up to 99%. The effects of the ligand structures on the enantioselectivity were also studied.A series of new optically active [2-（1-hydroxyalkyl）pyrrolidino]methylferrocenes were conveniently prepared from commercially available L-proline and ferrocenecarboxylic acid. The crystal structure of key intermediate was obtained. They were then applied to catalyze enantioselective addition of diethylzinc to arylaldehydes with enantioselectivity up to 99%. The effects of the ligand structures on the enantioselectivity were also studied.

关 键 词：chiral [2-（1-hydroxyalkyl）pyrrolidino]methylferrocene synthesis asymmetric addition diethylzinc arylaldehyde 

分 类 号：O629.711[理学—有机化学]