妊娠合并癫痫患者抗痫药浓度的观察  

SERUM LEVELS OF ANTI-EPILEPSY DRUGS IN PREGNANT WOMAN WITH EPILEPSY

作　　者：陈青[1] 张敬军[1] 孙思琴[1] 陈玉社 李钦文[1] 

机构地区：[1]山东省泰安卫生学校泰山医学院

出　　处：《泰山医学院学报》1996年第2期125-127,共3页Journal of Taishan Medical College

摘　　要：探讨妊娠合并癫痫患者抗病药物浓度的变化，前瞻性研究了４１例妊娠合并癫痫患者。用ＨＰＬＣ方法或ＴＤＸ仪器测定血浓度。结果妊娠期间１９例（４６％）患者发作频率增加，１７例（４２％）患者无发作，５例（１２％）患者发作频率同妊娠前。妊娠期抗痫药血浓度较妊娠前低。作者认为：对多年无发作者，妊娠前即停用抗痫药，活动性癫痫患者勿停止治疗。改变药物剂量不仅根据药物浓度，还要考虑发作频率，药物对胎儿的副作用等。To investigate the concentrations of anti-Epilepsy drugs during the course of preg-nancy,serurn levels of several anti-Epilepsy drugs in 41 pregnant women with epilepsy were studiedusing HPLE or TDX methods.The results showed that during pregnancy, occurrence rate increased in19 cases(46%),unchanged in 5 cases(12%)fand no occurrence in 17 cases(42%).Among them,theserum levels of A-Edrugs were lower than those before pregnancy.It is suggested that the A-Edrugs should be continued in those patients who have high frequent occurrence and quit in those withoutoccurrence for many years,the adjustment of the drugs should be depend on both serum concentrationand occurrence rate,and the side effects on infants as well.

关 键 词：癫痫 妊娠 抗痫药 血药浓度 

分 类 号：R714.25[医药卫生—妇产科学]