芪丹煎对动脉粥样硬化家兔载脂蛋白的影响  

Influence of Qidan decoctum on apolipoprotein of atherosclerosis rabbits

作　　者：杨森[1] 

机构地区：[1]河北医科大学门诊部,河北石家庄050017

出　　处：《现代中西医结合杂志》2005年第19期2513-2514,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察益气活血中药复方芪丹煎对实验性动脉粥样硬化(AS)家兔的影响,探讨该方防治AS导致心肌缺血的机制。方法采用酶法测定血清三酰甘油(TG)、总胆固醇(TC)、载脂蛋白AI(ApoAI)和载脂蛋白B(ApoB),电镜观察胸主动脉的病理改变。结果与模型组比较,芪丹煎可以明显降低血清TG(P<0.05)、TC和ApoB(P<0.01)水平,增加ApoAI含量(P<0.01)。结论降低血脂、调节载脂蛋白含量可能是芪丹煎抑制AS的机制。Objective It is to observe the influence of Qidan deooctum on experimental atherosclerosis （AS） rabbits and to discuss the mechanism of it preventing and curing myocardial ischemia induced by AS. Methods Serum TC, TG, ApoAI and ApoB were measured with enzyme method. The pathology change of aorta pectoralis was observed with electron microscope. Results Compared with model group, Qidan decoctum could obviously lower serum TG （ P 〈 0.05 ）, TC and ApoB （ P 〈 0.01 ）, and could increase ApoAI content （P 〈 0.01 ）. Conclusion Lowering blood fat and modulating apolipoprotein may be the mechanism of Qidan decoctum restraining AS.

关 键 词：芪丹煎 动脉粥样硬化 载脂蛋白 

分 类 号：R285.5[医药卫生—中药学]