148例铜绿假单胞菌感染病例的耐药监测和用药分析  

Drug-resistance Monitoring and Medication Analysis:Survey of 148 Pseudomonas Aeruginosa Infection Cases

作　　者：殷秀贞[1] 时萍[1] 彭红艳[1] 姜思通[1] 

机构地区：[1]青岛大学医学院附属医院,青岛市266003

出　　处：《中国药房》2005年第18期1406-1408,共3页China Pharmacy

摘　　要：目的:了解铜绿假单胞菌的耐药及用药现状,为临床控制其感染提供参考。方法:对我院2004年分离确认的148例铜绿假单胞菌感染病例所作药敏试验的敏感率进行统计,及作抗菌药物用药全程跟踪统计。结果:铜绿假单胞菌耐药现象严重,对所有抗菌药物都有不同程度的耐药;哌拉西林/他唑巴坦、头孢他啶、碳青霉烯类抗生素敏感率较高,分别为75.68%、73.65%、70.27%;第3代头孢菌素与其含抑酶剂的复合制剂交叉耐药现象严重且增长很快;药敏试验前敏感品种选用率不足50%。结论:及早进行菌株培养分离和药敏试验,不失为控制铜绿假单胞菌感染的有效举措。OBJECTIVE： To probe into the status quo of the drug resistance and the medication of pseudomonas aeruginosa so as to provide references for the clinic in the controlling of pseudomonas aeruginosa infection. METHODS： The susceptive rates of the susceptibility test performed on 148 pseudomonas areuginosa infection cases confirmed in 2004 in our hospital were collected statistically and a whole range tracking statistics were conducted on the use of antibacterials. RESULTS： Pseudomonas aeruginosa had a strong drug resistance, which had a different degree of drug resistance to all antibacterials; Antibiotics like piperacillin/tazobactam, ceftazidime and carbopenem took the lead in terms of their susceptive rates, which stood at 75.68%, 73.65% and 70.27%, respectively; The cross resistances of the third generation cephalosporins and the compound agents of the third generation cephalosporins and their enzyme inhibitor were serious and which kept increasing rapidly; The adoption rates for the susceptive kinds were less than 50% before the susceptibility test. CONCLUSION： An effective way to control pseudomonas aeruginosa infection is to conduct strain culture and isolation and perform susceptibility test as early as possible.

关 键 词：铜绿假单胞菌 抗菌药物 耐药监测 

分 类 号：R978.1[医药卫生—药品]