多索茶碱注射液与地塞米松磷酸钠注射液配伍稳定性考察  

Study on the Compatible Stability of Doxofylline Injection and Dexmethasone Sodium Phosphate Injection

作　　者：彭向前[1] 李军[2] 张鉴[2] 

机构地区：[1]山东大学药学院,济南市250012 [2]山东省立医院药剂科,济南市250021

出　　处：《中国药房》2005年第18期1419-1420,共2页China Pharmacy

摘　　要：目的:考察多索茶碱注射液与地塞米松磷酸钠注射液的配伍稳定性。方法:观察及测定多索茶碱注射液与地塞米松磷酸钠注射液在5%葡萄糖注射液中配伍后于25℃放置6h内的外观及pH值,并采用高效液相色谱法测定配伍液的含量。结果:与配伍后0h比较,配伍液放置6h内的外观色泽、澄明度及含量均无明显变化,而pH值有所升高。结论:多索茶碱注射液与地塞米松磷酸钠注射液在5%葡萄糖注射液中配伍后于25℃放置6h内质量稳定。OBJECTIVE： To study the compatible stability of doxofylline injection and dexmethasone sodium phosphate injection. METHODS： The changes in appearance and pH value of the mixture of doxofylline injection and dexmethasone sodium phosphate injection in 5% glucose injection within 6 hours at 2512 were observed and determined, the content of which was determined by HPLC. RESULTS： Compared with the solution at 0b of mixing, no significant changes were noted in color, clarity and content within 6 hours＇ mixing, however, there was an increase in its pH value. CONCLUSION： The mixture of doxophylline and dexmethasone in 5% glucose injection is stable in quality within 6 hours＇ mixing at 25℃.

关 键 词：多索茶碱注射液 地塞米松磷酸钠注射液 配伍 稳定性 高效液相色谱法 

分 类 号：R927.11[医药卫生—药学]