肾综合征出血热地鼠肾细胞灭活疫苗人群免疫的血清学效果观察  

Serological efficacy of the inactivated golden hamster kidney cell vaccine against hemorrhagic fever with renal syndrome in human trial

作　　者：任珂[1] 芦全香 宋干[3] 黄永成[4] 孙人和 王升 杭长寿[3] 回良杰[4] 刘海林 苑富莲 霍子威[3] 郭瑞琦 赵习芳[1] 丰有录 张全福[3] 张莉媛[1] 石振坤 李延军 潘天受 王忠平 孙秀芳 

机构地区：[1]山西省卫生防疫站,太原030012 [2]大同市卫生防疫站 [3]中国预防医学科学院病毒学研究所 [4]长春生物制品研究所 [5]山西省卫生厅

出　　处：《中华实验和临床病毒学杂志》1996年第1期10-12,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：为进一步了解肾综合征出血热家鼠型(Ⅱ型)地鼠肾细胞灭活疫苗人群免疫效果,我们于1993年1月至1994年3月应用长春生物制晶研究所生产的3批中试疫苗对136名志愿者进行人群免疫的血清学效果观察。结果,3批疫苗(92-1,92-2,92-3),2种免疫程序(0,28,42d 和0,28d)的4组接种者,首针免疫后56d,用微量细胞病变中和试验检测中和抗体,阳转率均达96%以上,抗体的几何平均滴度(GMT)为43.7。未发现严重的不良接种反应,表明疫苗的安全性较好。同批疫苗(92-1批)用2种免疫程序接种者,首针免疫后180d、360d 抗体阳性率与 GMT 均明显下降,首针免疫后1年再加强免疫1次,回忆反应都很良好,抗体阳性率迅速回升至96%以上,GMT 升为32.4,表明该批疫苗、2种免疫程序接种者有相似的良好血清学效果。In order to assess the serological efficacy of the inactivated golden hamster kidney cell(GHKC)vac- cine(type 11)against hemorrhagic fever with renal syndrome(HFRS),a human vaccination trial was conducted in a nouendemic area(Datong City)from January,1993 to March,1994.136 native volunteers were randomly selected and divided into 4 groups,in which,3 were vaccinated with each of the 3 lots of the vaccine(92-1,92-2 and 92-3 lots)and with the 3-dose schedule(0,28,42d),and the 4th group was vaccinated with the vaccine of lot 92-1,and with the 2-dose schedule(0,28d).It was shown that.the seroconversion rates of neutralizing antibodies(by MCPENT)56 days after the first dose of vaccination in vaccinees of all the 4 groups reached 98.5% (96.7%-100%),with the geometric mean titer(GMT)43.7.No serious untoward reaction was observed.The vaccinees of the 2 groups immunized with lot 92-1 vaccine by 2 immunization schedules were followed up by succes- sive blood-samplings on 180d and 360d after the first dose of vaccination.The positive rates and the GMT of the neutralizing antibodies declined obviously,but they got up rapidly after a booster dose with the same lot of vaccine. The positive rates returned to 98.1%(96.4%-100%)with the GMT 32.4.These results demonstrated that both the 3-dose and the 2-dose immunization schedules are effective for neutralizing antibody response,and the vaccine is relatively safe and serological effective.

关 键 词：肾病综合征 灭活疫苗 流行性出血热 

分 类 号：R692.03[医药卫生—泌尿科学]