米安舍林治疗精神分裂症后抑郁症43例  

Treatment of 43 Cases of Post-schizophrenic Depression with Mianserin

作　　者：张俊青[1] 王秋玲[2] 张增[2] 

机构地区：[1]山东省济宁市精神病防治院药械科,272051 [2]山东省济宁市精神病防治院精神科,272051

出　　处：《医药导报》2005年第10期889-890,共2页Herald of Medicine

摘　　要：目的比较米安舍林与阿米替林治疗精神分裂症后抑郁症的疗效与安全性.方法 86例精神分裂症后抑郁患者随机分为治疗组和对照组各43例,治疗组给予米安舍林30～90 mg·d-1,对照组给予阿米替林75～225mg·d-1,进行为期6周的随机对照试验,用汉密顿抑郁量表(HAMD)、阳性与阴性症状量表(PANSS)评定临床疗效,用不良反应量表(TESS)评定不良反应.结果米安舍林和阿米替林治疗精神分裂症后抑郁疗效相当(P＞0.05),其显效率分别为62.8%和65.1%,两组治疗前后HAMD、PANSS评分分别比较,均有极显著性改善(P＜0.01),但米安舍林起效快,且不良反应少而轻.结论米安舍林治疗精神分裂症后抑郁疗效肯定,用药安全,耐受性好.Objective To compare the therapeutic effectiveness and safety rate of mianserin and amitriptyline in the treatment of post-schizophrenic depression. Methods 86 patients with post-schizophrenic depression were randomly divided into two equal groups , the treatment group and the control group. Patients of the treatment group were given each 30-90 mg·d^-1 of mianserin PO, while patients of the control group were given each 75-225 mg·d^-1 of amitriptyline PO. The course of treatment in both groups lasted 6 weeks. The clinical therapeutic effectiveness was assessed with the Hamilton Depressive Scale （HAMD） and Positive and Negative Symptom Scale （PANSS） , while adverse reactions were appraised with the Treatment Emergent Symptom Scale （TESS）. Results The rates of excellent therapeutic effect of mianserin and amitriptyline were 62.8% and 65.1%, respectively （P〉0.05）. The differences between the HAMD and PANSS scores before and after the treatment in patients of both groups were highly significant （P 〈0.01）, showing striking improvement of the patients condition. However, mianserin started to act quickly , and its adverse reactions were less common and more trifling than those of amitriptyline. Conclusion Mianserin was shown to have definite therapeutic effect in the treatment of post-schizophrenic depression. It was also safe during medication and well-tolerated by the patients.

关 键 词：米安舍林 阿米替林 精神分裂症后抑郁 

分 类 号：R971.43[医药卫生—药品] R749.3[医药卫生—药学]