奎的平对精神分裂症患者生活质量的影响  

Effect of Quetiapine on the Quality of Life in Schizophrenics

作　　者：张传芝[1] 王秋玲[1] 时忠丽[1] 

机构地区：[1]山东省济宁市精神病防治院精神科,272051

出　　处：《医药导报》2005年第10期891-892,共2页Herald of Medicine

摘　　要：目的观察奎的平对精神分裂症患者生活质量的影响.方法符合CCMD-3诊断标准的精神分裂症患者62例,分为两组.治疗组30例,均给予奎的平300～600 mg·d-1,bid,PO;对照组32例,均给予氯氮平300～500mg·d-1,bid或tid,PO.两组均治疗6个月,观察两组精神分裂症患者的精神症状及生活质量的改变.结果两组患者精神分裂症阳性、阴性症状及PANSS总分的改善情况相似,差异无显著性(P＞0.05).治疗6个月后,治疗组患者生活质量的改变,除精神支柱外,其他均非常明显地提高;对照组患者生活质量部分提高,但对患者的生理领域、心理领域、独立性领域没有明显改善.结论奎的平比氯氮平更能改善精神分裂症患者的生活质量.Objective To survey the quality of life in patients with schizophrenia treated with quetiapine. Methods 62 patients meeting the CCMD-3 diagostic criteria for schizophrenia were assigned to 2 groups, the treatment group （n=30） and the control group （n=32）. Patients of the treatment group were given each 300 -600 mg·d^-1 of quetiapine, b. i. d. , PO. Patients of the control group were given each 300-500 mg·d^-1 of clozapine, b. i.d. or t. i. d. , PO. The course of treatment in both groups lasted 6 months. The Positive and Negative Symptom Scale （PANSS） was used to assess the therapeutic effectiveness, and changes in the quality of life in all of the patients were kept under observation. Results The differences were not significant between the 2 groups of schizophrenics with respect to the changes in the positive and negative symptoms as well as the total scores of PANSS （P〉0.05）. After the 6 month treatment, a striking improvement was demonstrated almost in every aspect of the quality of life in patients treated with quetiapine except for the spirit domain. In contrast, only partial improvement in the quality of life was shown in patients treated with clozapine, which had no help to the schizophrenics in the domains of physiology, psychology and independent character. Conclusion It was shown that quetiapine was superior to clozapine in improving the schizophrenics＇quality of life.

关 键 词：奎的平 氯氮平 生活质量 精神分裂症 

分 类 号：R971.41[医药卫生—药品] R749.3[医药卫生—药学]