电感耦合等离子质谱法测定常通口服液中铅的含量  

Determination of the Content of Lead in the Changtong Oral Liquid with Inductively Coupled Plasma-mass Spectrometry

作　　者：郭丹[1] 杨西晓[1] 侯连兵[1] 

机构地区：[1]南方医科大学南方医院药学部,广州510515

出　　处：《医药导报》2005年第10期934-935,共2页Herald of Medicine

基　　金：国家新药研究基金资助项目(基金编号:96-901-05-245)

摘　　要：目的建立中药常通口服液中重金属铅(Pb)的含量测定方法.方法采用电感耦合等离子质谱法测定常通口服液中铅的含量,RF功率1.35 kW,反射功率＜5W,采样深度6.8 mm,溶液提升量1 mL·min-1,氩气流量:冷却气12.0 L·min-1,辅助气1.0 L·min-1,雾化气1.0 L·min-1.结果铅在1～8μg·mL-1浓度范围内线性关系良好(r=0.999 2),平均回收率为99.12%,RSD=2.86%.结论该方法简单、快捷、灵敏,可用于常通口服液的质量控制,常通口服液中铅含量符合规定.Objective To set up a method for the determination of the content of lead （plumbum, Pb） in the traditional Chinese medicine changtong oral liquid. Methods Inductively coupled plasma-mass spectrometry （ICP-MS） was used for the determination of lead under the following conditions： forward power, 1.35 kW; reflection power, 〈 5 W; sample depth, 6.8 mm; cold argon gas flow, 12.0 L·min^-1; auxiliary argon gas flow, 1.0 L·min^-1, and nebulous argon gas flow, 1.0 L·min^-1. Results The calibration curve was linear when the concentrations of the heavy metal Pb were in the range of 1-8 μg·mL^-1 （r=0.9992）. The average rate of recovery of Pb was 99.12%, RSD=2.86% （n=5）. Conclusion The method was shown to be simple, rapid and sensitive and could be used for the quality control of the changtong oral liquid with respect to its content of Pb. The Pb content in the changtong oral liquid accorded with the national stipulations.

关 键 词：常通口服液 铅 电感耦合等离子质谱法 重金属 

分 类 号：R286[医药卫生—中药学] R927.2[医药卫生—中医学]