丙酸氟替卡松联合沙美特罗吸入治疗支气管哮喘  

Efficacy Evaluation of Inhaled Fluticasone Propionate and Salmeterol Combinated Treatment for Asthmatic Children

作　　者：姚劲[1] 秦铭[1] 季纯珍[1] 赵德育[1] 

机构地区：[1]南京医科大学附属南京儿童医院呼吸科,南京210008

出　　处：《实用儿科临床杂志》2005年第10期1036-1037,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的观察糖皮质激素与长效β2受体激动剂联合吸入治疗支气管哮喘的疗效。方法对47例诊断为支气管哮喘中重度持续的患儿予丙酸氟替卡松及沙美特罗联合吸入治疗。观察病人治疗前、治疗1周及治疗1个月时PEF值、哮喘症状计分、治疗第1周及第4周使用短效β2受体激动剂的天数、患儿对治疗的主观感受(或家长的评价)及治疗过程中的不良事件。结果治疗1周时PEF值、哮喘症状计分与治疗前相比显著缩短(P<0.01),治疗1个月时症状及肺功能均进一步改善。治疗第4周使用短效β2受体激动剂的天数与第1周相比有显著缩短(P<0.01)。结论糖皮质激素与长效β2受体激动剂有互补作用.对于中重度哮喘患儿,两者联合吸入治疗,有显著疗效。Objective To observe the efficacy of combinated inhaled glucocorticosteroid and long -β2 - agonist for asthmatic children, Methods Forty-seven children with moderate or severe persistent asthma were treated with inhalation of the fluticasone propionate and salmeterol. The PEF value and the mark according the symptom of asthma before and after treatment（week and month respectively） were recorded. At the same time the days of treatment the patient with the short-β2-agonist in the first week and the forth week respectively were noted. The subjective feeling and accident of patients also should he paid attention. Results There was significant difference （ P〈0.01 ） before and 1 week after treatment according PEF value and the mark of asthmatic symptom. Improvement of symptom and lung function were presented after treatment with fluticasone propionate and salmeterol for 1 month. There was significant difference between the days of treatrment with the short -β2- agonist in the forth week and the first week（ P〈0.01 ）. Conclusions Mutual pattern and mechanism exist between the glucocorticosteroid and long - β2 - agonist. The actions of them are evident in the treatment moderate or severe persistent asthmatic children.

关 键 词：哮喘 儿童 丙酸氟替卡松 沙美特罗 

分 类 号：R725.6[医药卫生—儿科]