妊高征患者血浆中分子物质含量变化及其临床意义  

Changes and clinical significances of middle molecular substances levels in the plasma of patients with pregnancy induced hypertension

作　　者：葛菲[1] 蒙玉舟[1] 吉丽敏[2] 程虹[1] 王丹妹[2] 刘彩萍[1] 王世雄[2] 

机构地区：[1]中南大学湘雅医学院附属海口医院海口市人民医院妇产科,570208 [2]海南医学院机能学实验室

出　　处：《中国妇幼保健》2005年第18期2330-2331,共2页Maternal and Child Health Care of China

基　　金：海口市重点科技计划项目(市科字〔1998〕27)

摘　　要：目的:探讨中分子物质(MMS)在妊娠高血压综合征(妊高征)患者血浆中的变化及其临床意义。方法:采用改进的紫外吸收法测定82例妊高征患者、98例正常妊娠妇女及66例正常非妊娠妇女血浆MMS含量。结果:妊高征患者血浆MMS水平显著高于正常妊娠妇女及正常非妊娠妇女(P<0.01);在轻、中、重度妊高征之间,血浆MMS有显著差别(P<0.01或P<0.05),MMS水平越高,妊高征病情越重;妊高征患者分娩后48 h其血浆MMS水平有所回落(P<0.05)。正常妊娠妇女及正常非妊娠妇女血浆MMS水平没有显著性差异(P>0.05)。结论:MMS与妊高征发病学有关,MMS可作为判断妊高征病情程度的指标之一。Objective： To study the changes and clinical significances of middle molecular substances levels in the plasma of patients with pregnancy induced hypertension （PIH） . Methods： Plasma MMS concentrations in 82 cases of PIH, 98 cases of normal pregnant women and 66 cases of healthy nonpregnant women were measured by an improved ultra - violet ray absorption method. Results： Plasma MMS concentrations were significantly higher in PIH group than those in normal pregnant women group and healthy nonpregnant women group respectively （P 〈0.01 ） . There was significant difference among plasma MMS levels from patients with mild, moderate, and severe PIH （P 〈 0. O1 or P 〈0. 05） , The higher plasma MMS levels, the worsen state of PIH. The plasma MMS levels decreased significantly in 48h post partum in PIH group （ P 〈 0. 05 ） . There was no obvious difference between plasma MMS levels from normal pregnant women and healthy nonpregnant women （ P 〉 0. 05 ） . Conclusion ： The changes of plasma MMS levels are believed to be association with pathogenesis of PIH and can be used as a biochemical marker for judging the progression of PIH.

关 键 词：妊娠并发症 心血管 高血压 中分子物质 

分 类 号：R714.24[医药卫生—妇产科学]