恒电流库仑分析法测定维生素C等药物  

CONSTANT CURRENT-COULOMETRIC ANALYSIS OF DRUGS HAVING REDUCTIVE PROPERTY(VITAMIN C,SODIUM METAMIZOLE DIMERCAPROL AND ETC)

作　　者：梁述忠[1] 

机构地区：[1]徐州工业职业技术学院,徐州221002

出　　处：《理化检验（化学分册）》2005年第9期671-673,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：江苏高校自然科学研究指导性计划项目(04KJD150182)

摘　　要：以恒电流库仑分析法测定维生素C、安乃近、二巯丙醇等药物的含量,以永停终点法指示库仑滴定终点,方法简便快速,相对误差为0.21%～0.28%,相对标准偏差(n=11)为0.027%～0.034%.Constant current-coulometric method was applied to the analysis for contents of some drugs （e. g. vitamin C, sodium metamizole, dimercaprol and etc） which showed reductive properties. Electro-generated iodine was used as titrant which quantitatively oxidized the reductive species of the sample and its content calculated according to the current （i） and time （t） of the electrolysis. Dead-stop method was used for the detection of endpoint of the coulometric titration. The proposed method was proved to be more accurate and precise than the conventional iodometric titration. In its application to the analysis of the above mentioned drugs, relative deviations in the range of 0. 21% to 0. 28%, and RSD＇s （n= 11） in the range of 0. 027% to 0. 034% were obtained which were about to times better than the iodometric method.

关 键 词：恒电流库仑分析法 维生素C 安乃近 二巯丙醇 

分 类 号：O657.31[理学—分析化学]