酗酒与扣带回前部膝周皮质5-羟色胺转运体的表达  

Expression of serotonin transporter in pregenual anterior cingulate cortex of alcoholics

作　　者：李双成[1] 石雄[2] 石葛明[1] 崔慧先[3] 王志红[2] 马常升[1] 

机构地区：[1]河北医科大学神经生物研究室,河北石家庄050017 [2]唐山市第八中学,河北唐山063000 [3]河北医科大学解剖教研室,河北石家庄050017

出　　处：《临床荟萃》2005年第20期1153-1155,共3页Clinical Focus

基　　金：河北省自然科学基金资助(300336)

摘　　要：目的观察酗酒者脑标本扣带回前部膝周皮质5-羟色胺转运体(SERT)的表达变化。方法以免疫放射自显影显示SERT在扣带回前部膝周皮质的免疫反应强度。结果健康者脑标本SERT标记信号在扣带回主要分布于胼胝体前部膝周皮质处;酗酒者脑标本,其正常分布于扣带回前部膝周皮质的SERT标记信号减弱;定量分析发现SERT免疫反应强度在酗酒者扣带回前部膝周皮质比健康者降低20.89%(P<0.01)。结论酗酒者扣带回前部膝周皮质5-羟色胺转运体表达降低。Objective To study the altered expression of serotonin transporter （SERT） in the pregenual anterior cingulate cortex （PACC） of postmortem human brain of alcoholics. Methods Immunoauto-radiography was used to reveal SERT immunoreactive intensity in PACC. Results Labeling signal of SERT was mainly found in PACC of the cingulate gyrus in healthy controls. In contrast, the labeling in PACC was reduced in alcoholics. Quantitative analysis revealed that 20.89% of labeling intensity of SERT decreased in PACC comparing with that of healthy control group（ P 〈0. 01）. Conclusion Reduced expression of SERT was shown in PACC of alcoholics.

关 键 词：酗酒 5羟色胺转运体 扣带回 免疫放射自显影 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]