重组人干扰素α-2b喷雾剂在人群中对风疹、麻疹病毒减毒活疫苗鼻腔接种后干预免疫效果的初步研究  

Preliminary study on nasal spray of interferon α-2b used for prevention of rubella and measles virus infections

作　　者：赵静[1] 朱凤才[2] 舒跃龙[1] 周蕊[2] 刘丽琦[2] 张丽兰 史智扬[1] 唐震[1] 林里卓[1] 喻志爱 张丽萍 张滨 侯云德[1] 

机构地区：[1]病毒生物技术国家工程研究中心北京金迪克生物技术研究所,北京100176 [2]江苏省疾病预防控制中心 [3]北京远策药业有限责任公司

出　　处：《中华实验和临床病毒学杂志》2005年第3期220-222,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的初步观察重组人干扰素α2b(rhIFNα2b)鼻腔喷雾剂对风疹、麻疹减毒活疫苗鼻腔接种后免疫效果的干预作用。方法选择合适人群进行对比试验,一组为干扰素(IFN)试验组,一组为对照组。IFN试验组提前2天使用rhIFNα2b喷雾剂,然后IFN试验组和对照组分别使用风疹、麻疹减毒活疫苗进行鼻腔接种。在疫苗接种前以及接种后第21和28天分别采集试验对象血清测定其对应的IgG特异性抗体,以抗体滴度的差异观察IFNα2b对病毒感染的干预效果。结果麻疹试验组和对照组的抗体差异分别为1.26(21d)和2.96(28d),差异有统计学意义;风疹试验组和对照组的抗体差异为0.95(21d)和0.37(28d),差异不明显。结论⑴单价麻疹和风疹疫苗鼻腔喷雾接种可以加强基础免疫;⑵rhIFNα2b鼻腔喷雾剂对风疹和麻疹减毒活疫苗鼻腔接种的免疫效果有一定的干预作用。Objective To evaluate the efficacy of the interferon α-2b nasal sprag in prevention ot rubella and measles virus infections. Methods The properly selected volunteer groups have been divided into interferon α-2b experimental and control group. The experimental group received interferon α-2b treatment by nasal spray for 2 days before the immunization, then buth groups were challenged with rubella and measles attenuated live vaccine respectively through nasal spray. The sera from pre-immunization and 21 and 28 days after immunization were collected to test the IgG antibody titers. The influence on the viral antibody titer reflects the viral preventive effect by interferon α-2b. Results The antibody titer difference of measles virus between experimental and control group was 1.26 （21 day） and 2.96 （28 day） , there were statistically difference between them ; the difference of rubella virus was 0.95 （21 day） and 0.37 （28 day） , but there were nostatistially differences fuund. Conclusion The preliminary, results showed that the interferon α-2b can be used as prevention method tot measles and rubella viral infections.

关 键 词：干扰素Α 风疹病毒 麻疹病毒 重组人干扰素Α-2B喷雾剂 麻疹减毒活疫苗 鼻腔喷雾剂 风疹疫苗 免疫效果 干预作用 接种后 

分 类 号：R96[医药卫生—药理学]