青少年肌阵挛性癫疒间的临床与脑电图44例分析  

Clinical expression and EEG features of 44 cases of juvenile myoclonic epilepsy.

作　　者：邱鹏玲[1] 姚佩丽[1] 孙道开[1] 

机构地区：[1]复旦大学附属儿科医院,上海200032

出　　处：《中国实用儿科杂志》2005年第9期550-552,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的总结青少年肌阵挛性癫疒间(JME)的临床及脑电图特点。方法对2000年11月至2004年11月就诊于复旦大学儿科医院的44例JME患儿的临床资料进行回顾性分析。结果44例JME患儿100%出现全身性肌阵挛发作,16例(36·4%)伴有失神发作,33例(75%)伴有全身性强直阵挛性发作,11例(25%)3种发作均有,6例(13·6%)只有全身性肌阵挛发作。首次就诊即确诊为JME13例,有31例曾误诊。清醒脑电图阳性率为50%,睡眠脑电图阳性率为95·5%,3例动态脑电图检查均阳性。JME患儿43例给予药物治疗,除1例死亡外,其中3例偶有肌阵挛性发作,余39例发作均控制。治疗过程中出现肌阵挛持续状态(JMES)者有7例,占15·9%。结论JME是儿童时期较常见的癫疒间综合征,临床医生在诊断中要多询问病史,结合规范的睡眠及动态脑电图检查,以提高检出率,并合理选择抗癫疒间药物。Objective To summarize our experience in the clinical expression and EEG features of patients with juvenile myoelonie epilepsy （JME） in ehidren. Methods Forty-four patients had been involved. Clinical data such as seizure type,cause of misdiagnosis,antiepileptie drugs,and EEG and sleep EEG had been analyzed. Results 100% of 44 cases showed myoclonic jerks ; 16 cases （36.4% ） also had typical absences ; 33 cases （75%） also had generalized tonic-clonic seizures;ll cases （25% ） had all three seizure types;6 cases （13.6% ）only had myoelonie seizures. 13 eases had been diagnosed at the first time. 31 cases were misdiagnosised. The positive rate for EEG was 50% , and for sleep EEG was 95.5%. 39 cases were seizure free. 7 cases （ 15.9% ） occurred myoelonie epileptic status. Conclusion JME is a very common form of epilepsy. Physicians should be aware of its characteristics. With the help of sleep EEG,physicians can get correct diagnosis,and choose the reasonable antiepileptie drugs for better control.

关 键 词：青少年肌阵挛性癫痫 全身性强直阵挛性发作 失神发作 肌阵挛性发作 睡眠脑电图 丙戊酸钠 

分 类 号：R72[医药卫生—儿科]