纳米靶向材料在基因治疗中的应用  

Application of nano-targeting material in gene therapy

作　　者：何喜生[1] 徐雪青[2] 沈辉[2] 黄向阳[3] 

机构地区：[1]华南理工大学材料学院,广州510641 [2]中山大学纳米技术研究中心,广州510275 [3]中科院广州能源研究所,广州510070

出　　处：《化工新型材料》2005年第8期18-20,共3页New Chemical Materials

摘　　要：纳米靶向材料作为基因药物载体,是一种新型的可控释体系,由于其具有超微体积,能穿过组织间隙被组织细胞吸收,还可通过人体最小的毛细血管进入体内,同时由于其结构的特异性,对组织细胞有靶向作用,因而具有广阔的应用前景。着重论述了纳米高分子及纳米无机材料在基因治疗中的研究进展,并对其在基因治疗中的应用前景提出展望。As a nonvirus gene carrier, nano-targeting material is a novel controlled release system. The nanoparticles can be licked up by the histiocytes through the interfaces,and can also traversing the minimal capillary vessel by virtue of its nanosize, what＇s more, for its special structure, the nano-material can be targeted to desined receptor, so we can conclude it must have a bright future in the gene therapy. This paper emphasizes to introduce the latest study of nano-ploymer and nano-inorganic material in gene therapy, and the future prospects of their application.

关 键 词：纳米粒子 靶向 基因治疗 纳米无机材料 应用 组织细胞 药物载体 毛细血管 高分子 控释 

分 类 号：R456[医药卫生—治疗学]