农药中间体2-氯-5-氨甲基吡啶的新合成方法  

The New Synthesis Technique for 2-Chloro-5-amino Methyl Pyridine

作　　者：吕兆萍[1,2] 杨红[1] 罗金香[1] 

机构地区：[1]南京农业大学理学院应用化学系 [2]南京航空航天大学材料科学与技术学院,南京210016

出　　处：《农药》2005年第10期466-466,共1页Agrochemicals

摘　　要：研究了2-氯-5-氨甲基吡啶的合成方法。该合成方法是由邻苯二甲酰亚胺、碳酸钾和2-氯-5-氯甲基吡啶发生Gabriel一步法缩合反应,其缩合产物先在强碱性溶液中水解,水解产物经过水蒸汽蒸馏,重结晶得2-氯-5-氨甲基吡啶。对合成的2-氯-5-氨甲基吡啶进行红外光谱分析和熔点测定,合成了具有较高收率的产品,产品总收率达86%。This paper studied the new synthesis method of 2-chloro-5-aminomethylpyridine, This method includes Gabriel condensation reaction by phthalimideso and 2-chloro-5-methylpyridine and K2CO3, then Gabriel condensation reaction product was hydrolyzed in basicity solution in the same time and hydrolytic product was distilled by vapor. By re-crytalizing the distilled product, we get 2-chloro-5-aminomethylpyridine. Then, the synthetic product was analyzed by IR and intermined by Kraemer-Sarnow method. The synthesis method shows that a high yield of the title product could be achieved and the total yield has been above 86%.

关 键 词：Gabriel缩合反应 水解反应 水蒸汽蒸馏 

分 类 号：TQ450.4[化学工程—农药化工]