卡托普利诱发咳嗽的高血压病患者血栓素B_2、6-酮-前列腺素F_(1α)的变化  

Changes of 11-dehydro-thromboxane-B_2 and 6-keto-prosta-glandin F_(1α)in hypertensive patients with cough induced by Captopril

作　　者：余静[1] 王琼英[1] 张缤[1] 阎炜[1] 赵锋[1] 杨成悌[1] 辛楠[1] 邝耀中[1] 

机构地区：[1]兰州大学第二医院心内科,甘肃兰州730030

出　　处：《临床荟萃》2005年第19期1090-1092,共3页Clinical Focus

基　　金：甘肃省科技攻关基金项目(NO:GS002043053)

摘　　要：目的探讨卡托普利诱发咳嗽的高血压病患者血浆和尿中血栓素B2(TXB2)、6酮前列腺素F1α(6-keto-PGF1α)水平的变化。方法采用放射免疫法测定38例咳嗽组及34例对照组高血压病患者服用卡托普利前后血浆及尿中TXB2、6-keto-PGF1α的水平。结果服用卡托普利后咳嗽组患者血浆TXB2的水平明显高于对照组[(99.75±27.56)ng/Lvs(84.87±15.08)ng/L],两者比较差异有统计学意义(P=0.016);咳嗽组患者服用卡托普利前[(192.92±47.78)ng/L]、服用卡托普利后[(153.80±25.35)ng/L]及停用卡托普利后[(169.73±38.07)ng/L]尿中6-keto-PGF1α水平差异有统计学意义(P=0.000)。结论卡托普利诱发咳嗽时患者血浆TXB2水平明显升高而尿中6-keto-PGF1α水平降低。Objective To observe the changes of plasma and urinary excretion of 11-dehydro-thromboxane-B2 （TXB2） and 6-keto-prostaglandin F1α （6-keto-PGF1α） in patients with essential hypertension who were treated with captopril. Methods The levels of plasma and urinary exeretion of TXB2 and 6-keto-PGF1α were detected by radioimmunoassay in 38 coughers and 34 controls. The samples were respectively collected before over dose, after overdose two weeks and withdrawal captopril 2 weeks. Results After two weeks of captopril treatment,the levels of plasma TXB2 in cough patients significantly increased than that in the controls [（99.75±27.56） ng/L vs （84.87±15.08） ng/L]（P=0.016）. Before overdose[（ 192.92±47.78） ng/L],after overdose two weeks[（153.80±25.35） ng/L] and withdrawal captopril two weeks[（ 169.73±38.07） ng/L], urinary recovery of 6-keto-PGF1α in cough patients had obviously difference （ P=0. 000）. Conclusion The imbalance between thromboxane and prostacyclin may represent a marker of patients susceptible to cough induced by angiotensin-converting-enzyme inhibition.

关 键 词：卡托普利 血栓素B2 6酮前列腺素F1α 咳嗽 

分 类 号：R544.1[医药卫生—心血管疾病]