吲哚的简易合成法  

A Simple Synthetic Method of Indole

作　　者：申屠有德 申屠阳 金毅强 童建成 刘志滨 

机构地区：[1]浙江普洛医药科技有限公司,浙江东阳322118

出　　处：《浙江化工》2005年第9期24-25,共2页Zhejiang Chemical Industry

摘　　要：用邻甲基苯胺和甲酸反应制得N-甲酰基邻甲基苯胺(甲酰化物),然后在氢氧化钾存在下,用甲苯作带水剂,邻甲基苯胺作溶剂制得甲酰化物钾盐,接着环合、水解制得吲哚,其收率达65%。Indole has been prepared by the reaction of O-toluidine and formic acid to obtain N-formacyl-O-toluidine （O-toluidide）,then in the presence of potassium hydroxide by toluone and O-toluidine used as water carrying reagent and solvent converted furter into potassium salt of O-toluidide,foUowed cyclization and hydrolysis. The yield of indole reached as high as 65%.

关 键 词：邻甲基苯胺 甲酸 氢氧化钾 N-甲酰基邻甲基苯胺(甲酰化物) 吲哚 吲哚 合成法 邻甲基苯胺 氢氧化钾 甲酰化 带水剂 甲酰基 反应 甲酸 

分 类 号：TQ253[化学工程—有机化工]