血脂康对高脂血症患者血脂及血管内皮功能的影响  

Effect of Xuezhikang on Blood Liquids Level and Vascular Endothelial Function of Patients with Hyperlipidemia

作　　者：王敏[1] 姚强[1] 黄世恩[1] 沈建瑾[1] 

机构地区：[1]浙江省中西医结合医院心内科,杭州310003

出　　处：《浙江中西医结合杂志》2005年第10期597-598,共2页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察血脂康对高脂血症患者血脂水平及血管内皮功能的影响。方法:98例高脂血症患者随机分为观察组49例和对照组49例。观察组口服血脂康胶囊,每天1.2g,连用8周;对照组口服普伐他汀片,每天20mg,连用8周。测定治疗前后两组血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及内皮素(ET)、一氧化氮(NO)水平。结果:治疗后,两组TG、TC、LDL-C、ET降低,HDL-C、NO升高,与治疗前比较,差异均有显著性意义(P<0.01或<0.05)。观察组与对照组比较,治疗后TG、TC、LDL-C降低及HDL-C升高差异均无显著性意义,但ET降低和NO升高差异有显著性意义(P<0.05)。结论:血脂康在改善高脂血症患者血脂异常同时可降低血内皮素、升高血一氧化氮水平,对血管内皮功能有改善作用。血脂康每天1.2g调脂程度与普伐他汀每天20mg相同,但改善血管内皮功能作用强于普伐他汀每天20mg。Objective： To explore the effect of Xuezhikang on blood liquids level and vascular endothelial function of patients with hyperlipidernia. Methods ： 90 eases with hyperlipidernia were divided randomly into observation group （45 cases） and contrast group （45 cases）. The observation group took orally Xuezhikang capsules with 1.2g/d for 8 weeks, and the ontrast group took orally Pravaehol tablets with 20mg/d for 8 weeks. Blood level of TG, TC, LDL-C, HLD-C, ET and NO were tested before and after treatment. Results： After treatment TG, TC, LDL-C and ET of both groups were decreased and HDL-C and NO increased. And the change had significant difference （P〈0. 01 or （P〈0. 05）. Compared with that of treatment group, the decrease of TG, TC and LDL-C and increase of HDL-C had scarcely significant difference, while the decrease of ET and increase of NO had significant difference （P〈0. 05）. Conclusion： Xuezhikang can adjust the abnormal blood liquids and improve the end othelial function of patients with hyperlipidemia. The effect of Xuezhikang （1.2g/d） is similar to that of pravaehol （20mg/ d） in adjusting blood liquids, but stronger than the later in improving endothelial function.

关 键 词：高脂血症 血脂康 内皮素 一氧化氮 血管内皮功能 高脂血症患者 血脂康胶囊 甘油三酯(TG) 内皮素(ET) 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 一氧化氮水平 LDL-C 

分 类 号：R259[医药卫生—中西医结合]