挤出滚圆法制备葛根芩连微丸  

Preparation of Gegen Qinlian Pellets by extrusion-spheronization method

作　　者：李青坡[1] 游剑[1] 杨蕾[1] 赵颖[1] 王永圣[1] 崔福德[1] 

机构地区：[1]沈阳药科大学药剂教研室,沈阳110016

出　　处：《中草药》2005年第10期1473-1476,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的制备能适合于工业化大生产具有较高载药量的葛根芩连微丸。方法采用挤出滚圆法制备葛根芩连微丸,对影响成球的4个关键参数水分比例、挤出速度、滚圆转速和滚圆时间进行筛选优化。结果制得的葛根芩连微丸载药量达70%、圆整度好、粒径分布窄,收率在90%以上。结论采用挤出滚圆法制备高载药量的葛根芩连微丸在工艺上是可行的,对中药微丸工业化大生产具有借鉴作用。Objective To prepare Gegen Qinlian Pellets with higher yield of drug loading and being good for industrial production. Methods The Gegen Qinlian Pellets were prepared by extrusion-spheronization. The effects of four key parameters on spheronization process were the proportion of bond, formulation. Results Gegen Qinlian Pellets presented perfect sphericity and narrow diameter distribution. Drug loading in the pellets could be up to 70% and yelid over 90%. Conclusion The Gegen Qinlian Pellets are successfully prepared by extrusion-spheronization. It presents a method for industrialized prodection of Chinese materia medica.

关 键 词：葛根芩连微丸 挤出滚圆法 制备 

分 类 号：R283.6[医药卫生—中药学] R286[医药卫生—中医学]