藁本内酯的稳定性及β-环糊精包合工艺的考察  

Stability of ligustilide and its β-cyclodextrin inclusion process

作　　者：李慧[1] 边宝林[1] 孟繁蕴[2] 王一涛[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700 [2]北京师范大学中药资源与资源药物研究所,北京100088

出　　处：《中草药》2005年第10期1483-1486,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的考察藁本内酯的稳定性,并采用β-环糊精包合,避免藁本内酯的异构化。方法自然条件或密闭、避光情况下,含藁本内酯的量下降显著。采用β-环糊精进行包合,正交试验优选了包合的最佳工艺,采用多种方法对包合物的形成进行了验证。结果DSC法、红外分光光度分析、GC分析显示:按最佳工艺制得的包合物与混合物有明显区别,藁本内酯被β-环糊精包合在分子腔中已经形成新的物相。结论藁本内酯常温下不稳定,β-环糊精包合可以改善它的稳定性。Objective To study the stability of ligustilide and the inclusion process in β-cyclodextrin to avoid its isomerization. Methods The content of ligustilide dropped severely even if it was kept away from layer and air under room temperature. The inclusion process with β-cyclodextrin was carried out on orthogonal design. The optimum conditions were determined and inclusion complex was made sure by many ways. Results The validated trials by DCS, IR, and GC could exhibit the obvious difference between mixture and inclusion complex which showed the form of a new phase, because of β-cyclodextrin and drugs in the molecular capsules. Conclusion Inclusion process with β-cyclodextrin can improve stability of ligustilide that is unstable in normal situation.

关 键 词：藁本内酯 稳定性 Β-环糊精包合 

分 类 号：R283.6[医药卫生—中药学] R286[医药卫生—中医学]