微波辐射下一步合成9-芳基-1,2,3,4,5,6,7,8,9,10-十氢-1,8-吖啶二酮  

One-pot Synthesis of 9-Aryl-1,2,3,4,5,6,7,8,9,10-decahydro- 1,8-acridinedione under Microwave Irradiation

作　　者：华国平[1] 李团结[2] 邹翔[2] 屠树江[2] 朱松磊[2] 章晓镜[2] 纪顺俊[3] 张勇[3] 

机构地区：[1]徐州建筑职业技术学院,徐州221008 [2]徐州师范大学化学系江苏省药用植物生物技术重点实验室,徐州221009 [3]苏州大学化学化工学院,苏州215006

出　　处：《有机化学》2005年第10期1294-1297,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20372057);江苏省自然科学基金(No.BK2001142);江苏省苏州大学化学化工学院有机合成重点实验室开放基金(No.S8109111);江苏省药用植物生物技术重点实验室开放基金(No.01AXL14)资助项目.

摘　　要：以芳醛、1,3-环己二酮、醋酸铵为原料在无溶剂条件下经微波辐射合成了一系列9-芳基-1,2,3,4,5,6,7,8,9,10-十氢-1,8-吖啶二酮.该反应的反应时间短、产率高、环境友好、后处理方便.产物的结构经红外光谱、核磁共振谱表征,3d的结构经单晶X射线衍射进一步确证.A series of 9-aryl-1,2,3,4,5,6,7,8,9,10-decahydro-1,8-acridinedione derivatives were synthesized via the reaction of aromatic aldehydes with 1,3-cyclohexanedione and ammonium acetate in solvent-free conditions under microwave irradiation by one-pot reaction. The reaction easily could be worked up with short reaction time, high yields and environmental friendliness. The structures of the products were confinned by IR and ^1H NMR spectra. The structure of 3d was further determined by X-ray analysis.

关 键 词：芳醛 1 3-环己二酮 吖啶二酮 微波辐射 微波辐射合成 环己二酮 一步合成 芳基 吖啶 单晶X射线衍射 

分 类 号：O626.2[理学—有机化学]