手性选择性阴离子交换膜的制备及性能  

Preparation of chiral selective anion-exchange membranes and their resolution performances

作　　者：林涛[1] 王军[1] 彭勇[1] 余立新[1] 

机构地区：[1]清华大学化学工程系,北京100084

出　　处：《清华大学学报（自然科学版）》2005年第9期1255-1257,共3页Journal of Tsinghua University(Science and Technology)

基　　金：国家自然科学基金资助项目(20376039);国家"九七三"重点基础研究项目(2003CB615701)

摘　　要：为得到较高通量的手性选择性阴离子交换膜,将β环糊精作为手性选择剂添加在膜相中,制得具有手性选择性的阴离子交换膜。将其用于拆分DL-对羟基苯甘氨酸外消旋混合物的电渗析过程。在碱性条件下L-对羟基苯甘氨酸优先通过手性阴膜,分离因子达1.25,通量达到60.4 g.m-2.h-1,验证了预期的拆分效果。使用普通阴膜,并在电渗析实验中对比了在料液中添加β环糊精以及不添加β环糊精的分离性能,β环糊精添加在料液中有明显的拆分效果,不添加β环糊精的普通电渗析几乎没有拆分效果。结果进一步验证了手性选择性来源于手性膜的β环糊精。Chiral selective anion-exchange membranes were prepared with β-cyclodextrin as the chiral selector to develop a new chiral selective membrane with a high enantiomer separation flux. The membranes were then used in the electrodialysis resolution process to separate DL-4-hydroxyphenylglycine racemic mixture. The results show that L-4-hydroxyphenylglycine is preferentially transported through the chiral selective anion-exchange membrane with basic conditions. The maximum selection factor is 1.25 with a flux of 60.4 g · m^-2 . h^-1. For comparison, conventional electrodialysis experiments with β-cyclodextrin in the feed had a selection factor of 0. 28 and without β-cyclodextrin the selection factor was about 1. These experiments show that β-cyclodextrin in the chiral selective membrane is the cause of the selectivity.

关 键 词：电渗析 阴离子交换膜 手性拆分 Β环糊精 对羟基苯甘氨酸 

分 类 号：TQ028.74[化学工程]