纳米细菌及其诱发肾结石形成的研究进展  

Nanobateria and its Research Progress in Inducing Kidney Stones Formation

作　　者：欧阳健明[1] 周娜[1] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,广州510632

出　　处：《微生物学通报》2005年第5期151-155,共5页Microbiology China

基　　金：国家自然科学基金资助项目(No.20471024);国家自然科学基金重点项目(No.20031010);广州市重点科技项目(No.2001-Z-123-01)

摘　　要：纳米细菌是近年来新发现的一种直径为纳米级且具有矿化能力的细菌。在肾结石形成过程中,纳米细菌可以作为结晶的活性中心,黏附、侵入并破坏肾集合管的上皮细胞和肾乳头细胞,形成磷灰石晶核,从而诱发肾结石形成。综述了肾结石中的纳米细菌及其诱发肾结石形成的体外模拟和动物学模型,讨论了纳米细菌与肾结石形成的关系。Nanobacteria （NB） is a kind of new bacteria with a diameter of 80～500 nm. It has specific mineralizing ability. As a active nidus it can attach, invade and damage the renal epithelium of collecting ducts and papilla, and then form apatite which being the center to induce formation of kidney stones. In the paper, the research progress on nanobateria contained in kidney stones and its role in kidney stones formation were summarized. The simulation in vitro and animal models of kidney stones formation induced by nanobateria were discussed.

关 键 词：纳米细菌 肾结石 生物矿化 

分 类 号：R692.4[医药卫生—泌尿科学]