司丙红霉素对大鼠的长期毒性  

Long-term toxicity of erythromycin propionate-N-acetylcysteinate in rats

作　　者：潘经媛[1] 邱银生[1] 严汉池[1] 凌飒[1] 

机构地区：[1]湖北省医药工业研究院药理毒理实验中心,武汉430061

出　　处：《中国新药杂志》2005年第9期1133-1135,共3页Chinese Journal of New Drugs

基　　金：湖北省重点科技项目(20001P1602)

摘　　要：目的:考察连续给予司丙红霉素(EPAC)对大鼠的毒性反应。方法:健康SD大鼠分别按体重随机分为低、中、高剂量组和蒸馏水组。低、中、高剂量组给药量分别为75,150和300mg·kg-1,连续灌胃给药90d。结果:司丙红霉素300mg·kg-1剂量组大鼠进食量减少,体重减轻,并伴有呕吐;150和300mg·kg-1剂量组大鼠血清总胆红素(T-Bil)及天冬氨酸转氨酶(AST)升高;300mg·kg-1剂量组血清丙氨酸转氨酶(ALT)升高。1个月恢复期后,150和300mg·kg-1剂量组各项指标均恢复正常。75mg·kg-1剂量组大鼠各项指标无明显影响。结论:司丙红霉素可引起可逆性毒性反应,大鼠口服司丙红霉素90d的安全剂量为75mg·kg-1。Objective： To assess the long-term toxicity of erythromycin propionate-N-acetylcy-steinate （EPAC） in rats. Methods：SD rats were randomly assigned to one of four diet groups; each group was orally supplemented either normal diets or diets with EPAC at a dose of 75, 150 or 300mg·kg^- 1 daily for up to 90d, respectively. Results： At the dose of 300mg·kg^- 1, the rats experienced lower appetite, weight loss and vomit as well as abnormal increases of ALT, T-Bil and AST levels. The dose of 150 mg·kg^-1 significantly escalated the serum T-Bil and AST levels. All of the abnormalities recovered in one month after the dosing of EPAC were terminated. No toxicity was observed in the 75 mg·kg^-1 group. Conclusion： Higher dosing of EPAC could produce reversible toxicities in rats.

关 键 词：司丙红霉素 长期毒性 大鼠 

分 类 号：R965.3[医药卫生—药理学] R978.15[医药卫生—药学]