齐酞酸钠在大鼠肠道吸收动力学研究  

Intestinal absorption of oleanolic acid hemidiphthalate sodium in rats in situ

作　　者：范玉玲[1] 崔福德[2] 张静[2] 

机构地区：[1]哈尔滨商业大学药物研究所,哈尔滨150076 [2]沈阳药科大学药剂教研室,沈阳110016

出　　处：《中国新药杂志》2005年第9期1147-1150,共4页Chinese Journal of New Drugs

摘　　要：目的:研究齐酞酸钠(OAHDPS)在大鼠肠道内的吸收特性。方法:采用大鼠在体小肠吸收实验方法,测定OAHDPS在不同剂量(100,50,25μg·mL-1)下结扎和不结扎胆管条件下的小肠吸收量和吸收速率常数(Ke),并比较各个肠段的吸收。结果:研究表明,OAHDPS在肠道内的吸收机制是被动扩散方式,且在小肠的吸收不受胆汁等分泌物的影响;在肠道正常pH值情况下,平均Ke为(0·162±0·012)h-1;各个肠段对OAHDPS均有吸收且Ke无显著差异。结论:在OAHDPS口服剂型设计时应首先考虑肠溶缓释制剂。Objective： To characterize the intestinal absorption of oleanolic acid hemidiphthalate sodium （OAHDPS） in rats .Methods： A rat intestine loop in situ technique was used to investigate the uptake rate Ke of OAHDPS in a series of concentration （25,50 and 100μg·mL^-1） at the intestine with or without ligation of bile ducts, respectively. The absorption coefficients at various intestinal segments were compared. Results：The kinetic analyses showed that the intestinal absorption of OADHPS obeyed with passive transport mechanism and first order kinetics with an absorption rate of （0.162±0.012） h^-1 under the normal pH environment. OADHPS could be absorbed at various segments of intestinal wall without significant differences of absorption coefficients. Conclusion： An enteric-coated sustained-release formulation might benefit the bioavailability of OAHDPS.

关 键 词：齐酞酸钠 在体肠道吸收 吸收动力学 

分 类 号：R965.1[医药卫生—药理学] R944.9[医药卫生—药学]