甲磺酸帕珠沙星注射液治疗急性细菌感染52例  

Clinical evaluation of pazufloxacin mesilate injection in adults with acute bacterial infections

作　　者：宁宁[1] 桂保松[1] 姚钢炼[1] 马力群[1] 张星映[1] 朱丹[1] 

机构地区：[1]西安交通大学第二医院,西安710004

出　　处：《中国新药杂志》2005年第9期1189-1192,共4页Chinese Journal of New Drugs

摘　　要：目的:评价甲磺酸帕珠沙星注射液治疗急性细菌性感染的有效性及安全性.方法:102例呼吸系统及泌尿系统感染患者随机分为试验组(n=52)和对照组(n=50),其中试验组用甲磺酸帕珠沙星500mg,bid,加入生理氯化钠溶液100mL静滴;对照组用盐酸左氧氟沙星200mg,bid,加入生理氯化钠溶液100mL静滴,疗程7～14d.结果:试验组总痊愈率和有效率分别为88.46%和96.15%,对照组总痊愈率和有效率分别为82.00%和92.00%,两组细菌清除率分别为95.35%和92.68%,两组比较差异均无显著性(P＞0.05).两组不良反应发生率分别为3.85%和7.69%,主要表现为转氨酶升高、局部刺激、恶心、呕吐、头痛、头晕、失眠、皮疹.结论:国产甲磺酸帕珠沙星氯化钠注射液的疗效和安全性与左氧氟沙星注射液相仿.Objective：To evaluate the efficacy and safety of pazufloxacin mesilate injection in the treatment of acute bacterial infections. Methods： A randomized and comparator controlled clinical study recruited 104 patients with respiratory and urinary tract infections, who were randomized 1 ： 1 to be i. v. infused with pazufloxacin mesilate 500 mg or Levofloxacin muriate injection 200 mg twice daily for 7 to 14 days. Results： The cure rates and effective rates of pazufloxacin and levofloxacin were 88.46% vs 82.0% and 96.15% vs 92.0%, respectively; the bacterial eradication rates were 95.36% vs 92.68% （ P 〉 0.05） ; the P values showed no significant difference. The incidence rate of adversereactions was 3.85 % vs 7.69%, including thirsty, nausea, vomiting, headache, dizziness, insomnia, rash, abdominal discomfort and elevated transaminases. Conclusion： Pazufloxacin mesilate bacterial infections injection offers an alternative in the treatment of acute bacterial infections.

关 键 词：甲磺酸帕珠沙星 左氧氟沙星 急性细菌感染 

分 类 号：R978.11[医药卫生—药品] R563.12[医药卫生—药学]