补肺活血胶囊治疗慢性肺原性心脏病120例  

A randomized and comparative control clinical study of the herbal capsules for nourishing lung and activating blood circulation for the treatment of chronic pulmonary cardiac disease

作　　者：杨波[1] 孟林敏 路浩[1] 王曙炎[1] 王萍 

机构地区：[1]河南省医学科学研究所,郑州450052 [2]河南省郑州市公路管理局医保办公室,郑州450052

出　　处：《中国新药杂志》2005年第9期1192-1195,共4页Chinese Journal of New Drugs

摘　　要：目的:评价中药补肺活血胶囊治疗慢性肺原性心脏病的有效性和安全性。方法:采用平行对照试验方法,160例肺心病患者随机分为试验组120例和对照组40例,分别口服补肺活血胶囊和金咳息胶囊,剂量均为1·4g,tid,疗程均为90d。结果:试验组用药后显效率和总有效率分别为45·8%和85·0%,对照组显效率和总有效率分别为20%和57·5%,试验组明显优于对照组(P<0·01)。治疗后试验组症状体征总积分、肺功能指标、血液流变学指标、动脉血气分析、免疫学指标均显著优于对照组(P<0·01或P<0·05)。两组各有1例患者用药期间出现轻度口干,多饮水后缓解。结论:补肺活血胶囊对肺心病的疗效优于金咳息胶囊,未发现明显不良反应。Objective：To evaluate the efficacy and safety of a new herbal capsules for nourishing lung and activating blood circulation （Bufeihuoxue-BFHX） for the treatment of chronic pulmonary cardiac disease （PCD）. Methods： 160 patients with PCD recruited in a randomized, parallel arm and comparative control clinical trial were randomized orally to receive the BFHX capsules （1.4 g, n = 120, rid） or the Jinkexi （JKX） capsules （1.4 g, n = 40, tid） for 90 days. Results： The overall efficacy in BFHX group was significantly superior to Jinkexi group （85.0 % vs 57.5 %, P 〈 0.05）. The BFHX patients experienced more significant improvements than JKX patients in general physical characters, pulmonary function index, hemodynamic index, arterial blood gas analyses and immunological index （ P 〈 0.05）. The adverse event reported in both groups was mild thirsty. Conclusion： The BFHX capsules offer an alternative in the treatment of PCD.

关 键 词：补肺活血胶囊 肺心病 金咳息胶囊 

分 类 号：R285.6[医药卫生—中药学] R289.5[医药卫生—中医学]