同步辐射X荧光测量大鼠脑中微量元素的分布(英文)  

Spatial Distribution of Elements in the Brain of Rats Measured by Synchrotron Radiation X-Ray Fluorescence

作　　者：冯流星[1] 肖海清[1] 何潇[1] 张智勇[1] 刘年庆[1] 赵宇亮[1] 黄宇营[2] 

机构地区：[1]中国科学院高能物理研究所核分析技术重点实验室 [2]中国科学院高能物理研究所北京同步辐射实验室,北京100049

出　　处：《高能物理与核物理》2005年第10期1012-1016,共5页High Energy Physics and Nuclear Physics

基　　金：国家自然科学基金(10490181)中国科学院核分析技术重点实验室和中国科学院重点方向性项目(KGCX-N01)资助~~

摘　　要：采用同步辐射微探针技术研究了正常大鼠脑中的微量元素的分布,并给出了二维空间分布图.结果显示:Cl,Ca,Zn主要集中分布在海马区,K主要分布在海马和皮层,而Cu的分布则相对无规律.元素的聚类分析结果表明,Cl和K的分布相关性较好.由于同步辐射X荧光技术可以更直观地给出脑组织的二维元素分布,因此这种方法可用于研究发生病变的脑中微量元素的变化.Spatial （two-dimensional） distributions of inorganic elements such as chlorine, potassium, calcium, iron, copper, and zinc in the brain slices of Wistar rats were measured by synchrotron radiation X-ray fluorescence （SRXRF） analysis. Differences in two-dimensional distribution of these elements were observed. Chlorine, calcium, and zinc were primarily concentrated in hippocampus, while the potassium concentration was relatively higher in both cerebral cortex and hippocampus. However, the distribution of copper was comparatively ruleless in the three brain regions. The cluster analysis of the elemental results shows that the spatial distribution of chlorine was correlated well with the distribution of potassium. Since SRXRF is possible to obtain a pictorial representation of the elemental concentrations in tissue sections of brain, this nuclear method may be useful to evaluate the ionic changes in injured brain tissues in relation to histological observations.

关 键 词：空间分布 微量元素 同步辐射X射线荧光 空间分布图 中微量元素 同步辐射 大鼠脑 X荧光测量 探针技术 集中分布 

分 类 号：R816.1[医药卫生—放射医学]