同步辐射硬X射线衍射增强峰位成像CT研究  

Computerized Tomography Using Peak-Position Image of Diffraction Enhanced Imaging

作　　者：袁清习[1] 王寯越[1] 朱佩平[1] 黄万霞[1] 舒航[1] 胡天斗[1] 吴自玉[1] 

机构地区：[1]中国科学院高能物理研究所,北京100049

出　　处：《高能物理与核物理》2005年第10期1023-1026,共4页High Energy Physics and Nuclear Physics

基　　金：国家自然科学研究基金重大项目(10490194)国家杰出青年基金(10125523)中国科学院高能物理研究所科技创新课题(U-540)资助~~

摘　　要：对于主要由轻元素组成的生物、医学样品,利用衍射增强成像技术可以观察到常规吸收成像无法观察到的内部微观结构,因而衍射增强成像具有较高的衬度和空间分辨率.选用苍蝇作为实验样品.在北京同步辐射装置上首次开展了衍射增强峰位成像CT实验.重建出的样品断层像显示其分辨率达到了几十μm水平.对于将衍射增强成像技术应用于生物和医学等领域具有重要意义.Using diffraction enhanced imaging （DEI）, high contrast and high spatial resolution can be obtained on biological and medical samples, which are mainly composed by light atoms such as C, H, O, etc. Experiments show that the crystal reflectivity is the highest at the peak position of the rocking curve, determining shortest collection time for imaging. Therefore, using the DEI technique at the peak position of the rocking curve results in a reduced dose delivered to the sample. Although planar images of DEI exhibit high contrast and spatial resolution, the problem of the superposition of structural information contained in thick samples can not be easily resolved. As a consequence it is mandatory to combine DEI with a computerized tomography （CT） method. At the Beijing Synchrotron Radiation Facility （BSRF） we selected a fly as a test sample to carry out CT experiments for the first time using the peak-position images of DEI. Experimental data show a spatial resolution of the CT images of about tens of micrometers, which implies possible applications of the DEI technique to image processes on biological and medical samples expanding the fields of application of the technique such as early diagnosis of specific diseases on cells or tissues.

关 键 词：衍射增强成像 同步辐射 CT 北京同步辐射装置 X射线衍射 成像技术 峰位 空间分辨率 实验样品 元素组成 

分 类 号：R814.42[医药卫生—影像医学与核医学]