2型糖尿病大血管并发症患者血浆脂联素质量浓度的变化  

Changes of plasma adiponectin concentration in type 2 diabetic patients with macrovascular complications

作　　者：韦秀英[1] 肖丽红[1] 

机构地区：[1]广西医科大学第五附属医院内分泌科,柳州545001

出　　处：《中国实用内科杂志》2005年第10期887-889,共3页Chinese Journal of Practical Internal Medicine

基　　金：广西卫生厅科研项目(z2004095)

摘　　要：目的了解2型糖尿病大血管并发症患者血浆脂联素质量浓度的变化.方法 2004-02～2005-02对广西医科大学第五附属医院内分泌科住院的2型糖尿病并大血管病变组49例,2型糖尿病无大血管病变组54例,健康对照组35名,测定其血浆脂联素水平,同时测定糖尿病患者的血糖、血压、血脂、C肽水平,比较脂联素质量浓度的变化,分析其影响因素.结果正常对照组、糖尿病无大血管病变组、糖尿病有大血管病变组脂联素质量浓度依次降低,分别为(16.37±3.03)mg/L,(6.69±4.42)mg/L,(4.08±3.24)mg/L,组间差异均有显著意义(P<0.001);其中糖尿病合并颈动脉增厚者血浆脂联素又明显低于糖尿病无颈动脉增厚者(P<0.01).结论血浆脂联素质量浓度在2型糖尿病患者中明显降低,合并大血管病变者降得更低,提示在2型糖尿病合并大血管并发症患者的发病因素中,脂联素的降低有相当重要的关系.Objective To investigate the changes of plasma adiponectin concentration in type 2 diabetic patients with macrovascular complications. Methods Forty - nine cases of type 2 diabetic patients with macrovascular complications, fifty - four cases of type 2 diabetic patients without macrovascular complications and thirty - five healthy people were investigated. Their plasma adiponectin levels was assayed. Meanwhile, the levels of blood pressure, plasma glucose, lipids and C - peptide were measured. The plasma adiponectin levels among three groups were compared, and the factors affecting the plasma adiponectin were analyzed. Results The plasma adiponectin levels in the group of type 2 diabetes without maerovascular complications were lower than in the control group and were the lowest in the group of type 2 diabetes with macrovascular complications. The plasma adiponectin levels of these three groups were （ 16. 37 ± 3. 03 ） mg/L, （6. 69 ±4.42） mg/L, （4. 08 ± 3.24） mg/L, respectively. The differences among the three groups were statistically significant （P 〈 0. 001 ）. Meanwhile the plasma adiponectin levels of type 2 diabetic patients with increased carotid IMT were lower than type 2 diabetic patients without increased carotid IMT （P 〈 0.001 ）. Conclusion The levels of plasma adiponectin in type 2 diabetic patient is significantly decreased, and even more in type 2 diabetic patient with macrovascular complications. The results suggest that the levels of plasma adiponectin are related to the macrovascular complications in type 2 diabetic patients.

关 键 词：糖尿病 大血管并发症 脂联素 

分 类 号：R5[医药卫生—内科学]