远志增强大鼠子宫平滑肌峰电活动实验研究  

Effects of Polygala tenuifolia Willd. decotion on myoelectric activity of uterine smooth muscle of virginal rats and its action mechanism

作　　者：徐敬东[1] 

机构地区：[1]首都医科大学基础医学院生理教研室,北京100054

出　　处：《中药药理与临床》2005年第4期44-46,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的探讨远志对未孕大鼠子宫平滑肌电活动的影响及其机制。方法用Biolap410生物机能仪进行记录,分别进行5种阻断剂使用前后,远志水煎醇沉液(以下简称远志)对子宫平滑肌电活动的影响。结果远志可使未孕大鼠子宫平滑肌的电活动频率加快,持续时间延长,峰面积加大。酚妥拉明、苯海拉明、异博定、消炎痛等能全部或部分阻断其兴奋作用,但阿托品无明显影响。结论远志对大鼠子宫平滑肌电活动增强作用主要通过H1受体、L型钙通道、α受体发挥作用,也与前列腺素的合成与释放有关,而与M受体无关。Objective： To study the effects of Polygala tenuifolia Willd. decotion on myoelectric activity of uterine smooth muscle of virginal rats. Method： To record the effects of Polygala tenuifolia Willd decotion on myoelectric activity of uterine smooth muscle of virginal rats with Biolap 410 Biological System. Five antagonists were used to study their mechanisms respectively. Result： Different dosages of water extract of Polygala tenuifolia （0.02g/kg,0.04g./kg,0.08g/kg）could significantly potentiate uterine myoelectric activity of virginal rats, increase the frequencies, prolong the duration and enlarge the spike area of electric activity regularly. Conclusion： The effect of Polygala tenuifolia on myoelectric activity of uterine smooth muscle may be mainly associated with H1 receptor, a-receptor, L-voltage-dependant calcium channels and prostaglandin synthese, nothing with M receptor.

关 键 词：子宫平滑肌 电活动 远志 阿托品 苯海拉明 酚妥拉明 异搏定 消炎痛 子宫平滑肌 未孕大鼠 峰电活动 远志 实验研 平滑肌电活动 L型钙通道 生物机能 时间延长 

分 类 号：R285[医药卫生—中药学]