钠钙交换器抑制药在心律失常治疗中的应用  

Application of sodium-calcium exchanger inhibitors to treatment of arrhythmia

作　　者：黄震华[1] 

机构地区：[1]上海第二医科大学附属第九人民医院心血管病研究室,上海200011

出　　处：《中国新药与临床杂志》2005年第10期829-832,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：心肌钠钙交换在调节心肌细胞内外钠、钙平衡中发挥重要作用。钠钙交换分为前向型和逆向型2种。在心力衰竭、心肌缺血、心肌再灌注等病理情况下,通过钠钙交换器的离子交换可产生致心律失常性的一过性内向电子流,引起延迟后除极和非折返激动型的室性心动过速。钠钙交换器抑制药在预防这些病理情况下的心律失常具有潜在的作用。Cardiac sodium-calcium exchange plays an important role in modulating the balance of sodium, calcium between inside and outside the cardiac cells. There are two types of cardiac sodium-calcium exchange： forward mode and reverse mode. In the pathogenesis of heart failure, ischaemia, reperfusion, ions exchange through sodium-calcium exchange may create arrhythmogenic transient inward current, induce delayed after-depolarisations and non-reentrant ventricular tachycardia. Sodium-calcium exchanger inhibitors have the potential effect in preventing arrhythmia for these pathologic conditions.

关 键 词：钠钙交换蛋白 心力衰竭 充血性 心肌缺血 心肌再灌注 心律失常 抗心律关常药 钠钙交换器抑制药 

分 类 号：R972.2[医药卫生—药品] R541.7[医药卫生—药学]