转反义PEP基因油菜超油1号菜籽油毒理性评价  

A study on toxicological evaluation of oil from Anti-PEP transgenic rape Chaoyou No.1

作　　者：胡张华[1] 王茵[2] 郎春秀[1] 陈建国[2] 吴关庭[1] 来伟旗[2] 黄锐之[1] 梅松[2] 金卫[1] 傅颖[2] 陈锦清[1] 

机构地区：[1]浙江省农业科学院病毒学与生物技术研究所,浙江杭州310021 [2]浙江省医学科学院,浙江杭州310013

出　　处：《中国油料作物学报》2005年第3期7-12,共6页Chinese Journal of Oil Crop Sciences

基　　金：国家转基因植物专项(TY03B1902);国家863计划资助项目(2001AA212141);国家自然科学基金资助项目(30370896)

摘　　要：为评价转反义PEP基因油菜超油1号菜籽油的食用安全性,对该样品进行了急性毒性试验和致突变试验。结果表明,转反义PEP基因超高油油菜菜籽油属无毒级,无致突变作用。大鼠90d喂养试验结果显示,各试验组大鼠体重、进食量、食物利用率、血常规、脏体比及病理组织学观察等各项指标与阴性对照均无显著性差异,无作用剂量为10.0m l/kg体重。In order to evaluate the food safety of anti - PEP transgenie rape Chaoyou No. 1, acute toxieity and mutagenesis experiments were conducted. Results showed that the oil made from Chaoyou No. 1 ranked as nontoxic class and no mutagenesis action was found. In a 90 - day feeding test with rats, no marked differences in appearanee, body weight, food intake, feed utilization rate, organ relative weight and hemogram of rates were observed between all treated groups and the control, and no pathological changes found in organs such as liver and kindney, with none effect dosage being 10.0ml/kg.

关 键 词：反义PEP基因 超油油菜 毒性试验 致突变 

分 类 号：S859.82[农业科学—临床兽医学] S565.4[农业科学—兽医学]