新型生物活性材料的设计和研究进展  

Design and Research Progress of the Novel Bioactive Material

作　　者：王璐[1] 王德平[1] 黄文旵[1] 宁佳[1] 郁美娟[1] 

机构地区：[1]同济大学材料科学与工程学院,上海200092

出　　处：《材料导报》2005年第9期97-99,104,共4页Materials Reports

基　　金：上海市科委纳米专项基金(0452nm059)

摘　　要：生物活性材料是生物医用材料领域中一个重要的研究方向。研究表明,在体液的作用下这类材料的表面能够形成 Si—OH、Ti—OH、Ta—OH、—COOH 和 PO_4H_2等功能基团,从而诱导类骨磷灰石层生成并与骨发生键合。综述了人们利用医用金属进行表面生物活化或通过有机/无机复合的方法得到力学性能良好的新型生物活性材料,为人工植入体的临床应用提供了更广阔的前景。Bioaetive material is one of the most significant research fields in biomaterials. Researches indicate that the surface of these materials could produce functional groups under the effect of body fluid, e. g., Si-OH、Ti-OH、Ta-OH,-COOH and PO4H2, subsequently, the functional groups could induce the formation of a bone-like apatite layer on their surtaces, and thus bond to the bone through this atmtite layer. This article summarizes the novel bioactive material with excellent mechanical property and bioactivity prepared by the chemical bio-activation of metals surface and composition of organic/inorganic materials. The methods provide extensive clinical applications in the future.

关 键 词：生物活性 功能基团 金属表面生物活化 

分 类 号：TB332[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]