复方丹参滴丸联合曲美他嗪治疗老年不稳定心绞痛疗效观察  

Observation on Effect of Compound Danshen Droplet-pill Combined with Trimetazidine in Treating Senile Unstable Angina Pectoris

作　　者：邱忠霞[1] 马贺军[1] 王涤非[1] 

机构地区：[1]中国医科大学附属第一临床学院老年病教研室,沈阳110001

出　　处：《中国中西医结合杂志》2005年第9期787-789,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨复方丹参滴丸联合曲美他嗪(TMZ)治疗老年不稳定心绞痛的疗效。方法老年不稳定心绞痛120例,随机分为两组,治疗组(60例,复方丹参滴丸联合曲美他嗪治疗)及对照组(60例,常规抗心绞痛西药治疗)。观察心绞痛缓解情况、心律失常发生率、心肌梗死及猝死发生率、心电图心肌缺血改善情况及部分心功能指标改善情况。结果心绞痛缓解总有效率治疗组78.3%,对照组53.3%,两组比较差异有显著性(P<0.05)。心律失常发生率治疗组18.2%,对照组30.0%;急性心肌梗死及猝死发生率治疗组无,对照组5.0%,两组比较差异有显著性(P<0.05)。治疗组心电图心肌缺血及部分心功能指标均有所改善。结论复方丹参滴丸联合曲美他嗪治疗老年不稳定心绞痛疗效明显优于单用西药治疗的对照组。Objective To investigate the effect of compound Danshen Droplet-pill （DS） combined with trimetazidine （TMZ） in treating senile unstable angina pectoris （SUAP）. Methods One hundred and twenty patients with SUAP were eaually and randomly divided into 2 groups, the treated group and the control group. Changes of angina, occurrence of arrhythmia, myocardial infarction and sudden death, myocardial ischemia in ECG and partial indexes of heart function were observed. Results The total effective rate in the treated group was 78.3 %, while that in the control group was 53.3 %, comparison of the two groups showed significant difference （P〈 0.05）. The incidence rate of arrhythmia in the two groups was 18.2 % and 30.0 % respectively and that of acute myocardial infarction and sudden death was 0 and 5.0% respectively, also showed significant difference between them （P 〈 0.05）. Condition of myocardial ischemia revealed in ECG and partial indexes of heart function in the treated group were all improved to certain extent. Conclusion DS combined with TMZ is superior in treating SUAP.

关 键 词：老年人 不稳定心绞痛 曲美他嗪 复方丹参滴丸 曲美他嗪(TMZ) 老年不稳定心绞痛 疗效观察 治疗组 联合 急性心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]