腰痹通胶囊对脊髓损伤内皮素-1影响的实验研究  

Experimental study of Yaobitong capsule on ET-1 of spinal cord injury rats

作　　者：张爱民[1] 范志勇[1] 史正亮[1] 周学智[1] 马维[1] 

机构地区：[1]河北医科大学第二医院骨科,石家庄050000

出　　处：《河北中医》2005年第9期703-704,共2页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察腰痹通胶囊对大鼠脊髓损伤(SCI)组织中内皮素1(ET1)含量的影响。方法健康SpragueDawley大鼠48只,采用Allen法复制大鼠脊髓损伤模型后,随机分为腰痹通胶囊组、强的松龙组、模型组及空白组,每组12只。腰痹通胶囊组予腰痹通3.2g生药(kg·次)灌胃,强的松龙组予强的松龙6ml(kg·次)灌胃,模型组予0.9%氯化钠注射液2ml次灌胃,各组均每日灌胃2次。空白组保持相同条件,正常饲养,不做其他处理。观察24h、2d、5d后损伤脊髓组织中ET1含量变化。结果腰痹通胶囊组与强的松龙组24h内对ET1影响无显著性差异。2d后,腰痹通胶囊组ET1含量明显低于强的松龙组(P<0.05)。结论在SCI的继发性损伤过程中,腰痹通胶囊有明显的治疗作用。Objective To ohserve the influence of Yaobiteng on ET-1 in spinal cord injury （ SCl ） rats. Methods 48 healthy Sprague Dawley rats made into SCI models by applying Inpmved Allen＇s method were divided into four groups： Yaobitong group （ n = 12）, prednisone group （ n = 12）, model group （ n = 12） and blank group （ n = 12）. Bats in the Yaobitong group were orally administrated Yaobitong 3.2 g/kg, two times a day. Rats in the prednisone group were orally given prednisone 6 ml/kg, two times a day. Bats in the model group were orally administrated 0.9% sodium chloride injection2 ml/kg, two times a day. Bats in the blank gronp were fed normally in the same condition withont pharmaceutical intervene. The level of ET-1 was observed on rats in different groups in 24 honr, the second day and the fifth day after the model was made. Results There is no marked difference of ET-1 between Yaobitong group and prednisone group within 24 hours. The level of ET-1 in the Yaobitong group is significantly lower than that in the prednisone group after two days intervene （ P 〈 0.05）. Conclusion Y aobitong cat, de has a definite effent on SCI,

关 键 词：腰痹通胶囊 脊髓损伤 内皮素-1 实验研究 

分 类 号：R651.2[医药卫生—外科学] R826.64[医药卫生—临床医学]