雷公藤总甙对冠状动脉支架术后再狭窄的影响  

A sustain adminstration of Tripterygium Glycosides to reduce restenosis after coronary stenting

作　　者：陈广华[1] 宋开友[1] 

机构地区：[1]临沂市人民医院心内科,山东临沂276003

出　　处：《华夏医学》2005年第4期507-509,共3页Acta Medicinae Sinica

摘　　要：目的:探讨雷公藤总甙对减少冠状动脉支架术后再狭窄及心脏事件发生率的影响。方法:80例患者随机分为两组,对照组给予常规治疗,治疗组在常规治疗的基础上加用雷公藤总甙6个月,所有的患者在6个月后复查冠状动脉造影,观察两组患者支架内再狭窄的发生率和心脏事件的发生率。结果:两组患者在临床特征和冠状动脉造影量化分析上无明显差异(P>0.05),6个月后两组患者支架内再狭窄的发生率和心脏事件的发生率有明显的差异(P<0.05)。结论:雷公藤总甙可以减少冠心病患者支架内再狭窄和心脏事件的发生率。Objective ：To test whether a sustain oral administration of Tripterygium Glycosides reduces restenosis after coronary stenting in patients. Methods：Eighties patients were randomly assigned to receive Tripterygium Glycosides （50mg/d） at least 3 days before stenting and continued on the same medication over a period of months. The primary end point was angiographic restenosis at 6 months angiography. Results ： Baseline clinical and angiograpphic variable were similar between the two groups. Angiographic 6 months was done in 66 patients and restnosis rate was significant different between the two groups（8. 82% vs 15.6% P=0. 041）. Conclusion：A sustained oral administration of tripterygium glycosides is effective to reduce restenosis after stenting in coronary heart disease.

关 键 词：雷公藤总甙 冠状动脉支架 再狭窄 

分 类 号：R543.3[医药卫生—心血管疾病] R541.4[医药卫生—内科学]