虎眼万年青单萜内酯新成分的分离及结构鉴定  

Isolation and Structure Identification of Novel Monoterpene Lactone from Ornithogalum Caudatum Ait

作　　者：白进发[1] 刘志强[1] 王淑敏[1] 宋凤瑞[1] 刘淑莹[1] 

机构地区：[1]中国科学院长春应用化学研究所新药研究实验室

出　　处：《高等学校化学学报》2005年第10期1817-1819,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20173057);吉林省科技厅自然科学基金(批准号:20030916-2)资助

摘　　要：对虎眼万年青氯仿提取物进行柱层析分离,得到一种单萜内酯(Loliolide)化合物(6-羟基-4,4,7 a-三甲基-5,6,7,7 a-四氢-4H-苯并呋喃-2-酮),用红外光谱和核磁共振波谱确定了该化合物的结构,并用电喷雾多级串联质谱对化合物的裂解机理进行了研究.通过比旋光度和核磁共振氢谱确定了化合物的立体构型.A kind of monoterpene lactone, 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydro-4H-benzofuran- 2-one, was isolated from Ornithogalurn Caudaturn Air, whose structure was confirmed by IR and NMR methods, and its fragmentation pathway was studied by ESI-MS^n. The stereo-structure of the compound was identified by the degree of specific rotation and ^1 H NMR. The experimental results demonstrate that the compound is firstly found in this kind of plant.

关 键 词：虎眼万年青 单萜内酯 对映异构体 

分 类 号：O657[理学—分析化学]