聚苯乙烯负载的β-溴乙烯基硒化合物的合成及其在固相合成多取代烯烃中的应用  

Synthesis of Polystyrene-supported Selenovinyl Bromide and Its Application in the Solid-phase Synthesis of Polysubstituted Olefins

作　　者：汤峨[1] 许建峰[1] 黄宪[1] 

机构地区：[1]浙江大学西溪校区化学系,杭州310028

出　　处：《高等学校化学学报》2005年第10期1849-1851,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(基金号:20272050);浙江省院士基金资助.

摘　　要：Organoselenium reagents are powerful tools for the preparation of small organic molecules.A simple preparation of polystyrene-supported（E）-1-bromo-2-selenoethylene was reported.In the presence of NiCl2（PPh3）2 catalyst,polystyrene-supported（E）-1-bromo-2-selenoethylene reacted with different Grignard reagents to offer（E）-1,2-disubstituted ethenes or trisubstituted ethenes.The evident advantages of this reaction are easy operations,odorlessness,good yields of the products.Organoselenium reagents are powerful tools for the preparation of small organic molecules. A simple preparation of polystyrene-supported （E）-1-bromo-2-selenoethylene was reported. In the presence of NiCl2 （ PPh3 ） 2 catalyst, polystyrene-supported （E） -1-bromo-2-selenoethylene reacted with different Grignard reagents to offer（E）-1 ,2-disubstituted ethenes or trisubstituted ethenes. The evident advantages of this reaction are easy operations, odorlessness, good yields of the products.

关 键 词：β-溴乙烯基硒化合物 多取代烯烃 固相合成 

分 类 号：O621[理学—有机化学]