穿心莲的化学成分  

Chemical Constituents from Leaves of Andrographis paniculata

作　　者：王国才[1] 胡永美[1] 张晓琦[2] 叶文才[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210038 [2]暨南大学中药及天然药物研究所,广州510632

出　　处：《中国药科大学学报》2005年第5期405-407,共3页Journal of China Pharmaceutical University

摘　　要：目的:研究穿心莲(Andrographis paniculata)叶中的活性成分。方法:用各种色谱方法进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果:从穿心莲叶中分离得到6个化合物,分别鉴定为:8-甲基新穿心莲内酯苷元(8-methylandrograpanin,Ⅰ)、3-脱氢脱氧穿心莲内酯(3-dehydrodeoxyandrographolide,Ⅱ)、新穿心莲内酯苷元(andrograpanin,Ⅲ)、8(17),13-ent-labdadien-15→16-lactone-19-oic acid(Ⅳ)、β-谷甾醇(Ⅴ)和胡萝卜苷(Ⅵ)。结论:化合物Ⅱ和Ⅲ为新天然产物,化合物Ⅳ和Ⅴ为首次从该植物中分离得到。AIM ： To study the bioactive ingredients of leaves of Andrographis paniculata Nees.. METHODS： The constituents were isolated and purified by column chromatography. Their structures were identified according to their physical and chemical properties and spectral data. RESULTS： Six compounds were isolated from the leaves of Andrographis paniculata, and their structures were identified as 8-methylandrograpanin （ Ⅰ ）, 3-dehydrodeoxy- andrographolide（ Ⅱ ）, andrograpanin （ Ⅲ ）, 8 （ 17 ）, 13-ent-labdadien-15→ 16-1actone -19-oic acid （ Ⅳ ）, β-sitosterol （Ⅴ） and daucosterol （Ⅵ）, respectively. CONCLUSION： Compounds Ⅰ and Ⅱ were classified as new natural products. Compounds Ⅳ and Ⅴ were isolated from this plant for the first time.

关 键 词：穿心莲 化学成分 二萜 8-甲基新穿心莲内酯苷元 3-脱氢脱氧穿心莲内酯 

分 类 号：R284[医药卫生—中药学]