表面活性剂复配制备稳定的固体脂质纳米粒混悬液(英文)  

Preparation of Stable Solid Lipid Nanoparticles (SLNs) Suspension with Combined Surfactants

作　　者：侯冬枝 谢长生[1] 平其能[2] 

机构地区：[1]华中科技大学材料学院模具技术国家重点实验室,武汉430074 [2]中国药科大学药学院,南京210009

出　　处：《中国药科大学学报》2005年第5期417-422,共6页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.50271029)~~

摘　　要：目的:表面活性剂在固体脂质纳米粒的制备过程中扮演着重要角色,为规避药物对体系的影响,本文选用4种表面活性剂制备了空白而具有良好物理稳定性的固体脂质纳米粒混悬液。方法:用激光散射粒度仪和Zeta电位分析仪(LD)检测平均粒径、颗粒分布范围和Zeta电位,另外还进行了DSC热分析和颗粒形态的TEM观察。结果:离子型表面活性剂脱氧胆酸钠可以提高纳米粒的Zeta电位从而提高系统物理稳定性,但乳化率低;非离子乳化剂Pluronic F-68可以起到空间稳定的作用从而避免胶体系统中颗粒的聚结。结论:4种表面活性剂的复配[两种非离子乳化剂(Pluronic F-68和Tween80),离子型表面活性剂(脱氧胆酸钠)以及卵磷脂]可以制备稳定6个月而不分层的纳米混悬液。AIM：Surfactants and their blend play important roles in the preparation of solid lipid nanoparticles （SLNs）. In this study, four typos of surfactant were employed to investigate the influence of the surfactants on proporties of SLNs in the absence of model drugs thereby avoiding the interaction between the surfactant and the drug. METHODS：The physicochemical properties of the colloidal systems, such as mean particle size, distribution range and Zeta potential, were investigated by laser diffractometry and the DSC analysis was porformed as well. RESULTS： It was found that ionic surfactants, such as sodium deoxycholate, increased the Zeta potential of nanoparticles leading to improve the physical stability of the system. But it showed obviously relative low emulsification efficiency in the preparation. Non-ionic emulsifier, especially Pluronic F-68, offered additional steric stabilization effect avoiding aggTegation of the fine particles in the colloidal system. CONCLUSION： The formulation in the study for the first time combined four types of additives including ionic surfactant （sodium deoxycholate）, nonionic emulsifier （Pluronic F-68 and Tween-80）, and lecithin to obtain favorably stable nanosusponsion, which could stabilize for more than six months without creaming.

关 键 词：固体脂质纳米粒 表面活性剂混合物 ZETA电位 

分 类 号：R94[医药卫生—药剂学]