促性腺激素释放激素激动剂治疗子宫腺肌病26例疗效观察  

Gonadotropin releasing hormone agonist in the treatment of 26 adenomyosis

作　　者：夏薇[1] 康佳丽[1] 张爱云[1] 

机构地区：[1]广州市第一人民医院妇产科,510180

出　　处：《中国实用妇科与产科杂志》2005年第10期620-622,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：广东省卫生厅基金资助项目(A2002565)

摘　　要：目的探讨促性腺激素释放激素激动剂(GnRHa)治疗子宫腺肌病的临床疗效。方法2003年1月至2004年1月广州市第一人民医院对26例子宫腺肌病患者予GnRHa3.6mg皮下注射,每4周1次,同时加用利维爱1.25mg/d口服,两者均连用6个月。治疗前后观察月经量、痛经程度及子宫体积等变化,并进行血癌抗原(CA125)、抗子宫内膜抗体(EMAb)及性激素水平测定。结果治疗后随访6个月,26例患者中20例月经量明显减少;痛经程度分级明显降低,痛经缓解率达100%;子宫体积平均缩小56%;血清CA125、EMAb及性激素水平均显著降低;10例不孕患者中治疗后,妊娠率达50%。结论GnRHa能有效控制子宫腺肌病症状,提高妊娠率,并可诱导围绝经期妇女闭经。Objective To study the clinical efficacy of gonadotropin releasing hormone agonist （GnRH-a） in the treatment of adenomyosis. Methods 26 patients with adenomyosis were treated with GnRH-a 3.6mg every four weeks and Livial which was used as add-back therapy 1.25mg everyday for 6 months from Jan 2003 to Jan 2004. The change of the symptoms and the uterine volume were investigated. And the level of serum CA125, EMAb and sexual hormone were detected both before and after therapy, Results After the therapy, we observed that the bleeding volume and the degree of the dysmenorrhea were obviously decreased. The reliving rate of dysmenorrhea was 100%. The uterine volumn was reduced at 56%. And the level of serum CA125.EMAb and the sexual hormones decreased significantly. The pregnant rate was 50%. Conclusion GnRH-a is effective in the treatment of adenomyosis. It can also improve the pregnant rate and induce amenorrhea.

关 键 词：促性腺激素释放激素激动剂 子宫腺肌病 治疗 

分 类 号：R71[医药卫生—妇产科学]