盐酸西替利嗪巴布剂的工艺优化  

Optimized Preparation of Cetirizine Hydrochloride Cataplasm

作　　者：韩璐[1] 胡晋红[1] 朱全刚[1] 

机构地区：[1]第二军医大学附属长海医院药学部,上海200433

出　　处：《中国医药工业杂志》2005年第10期611-613,共3页Chinese Journal of Pharmaceuticals

基　　金：全军医药卫生科研基金课题(01Z066)

摘　　要：考察了对盐酸西替利嗪巴布剂黏性影响较重要的3个辅料的用量,并研究了优化处方的含水量、黏性及体外释放度的关系。结果表明,随巴布剂含水量的减少,黏性逐渐减弱,释药速度减慢。60℃干燥9h,含水量为23%,黏性及体外释放均较好。The amounts of three excipients that had significant influence on viscosity of cetirizine hydrochloride cataplasm were investigated. The relationship of water content, viscosity and in vitro release of the product prepared by optimized formulation was examined. The results showed that the viscosity and release rate declined with the decreasing of water content. The viscosity and in vitro release of the product dried at 60℃ for 9h with 23 % water content were satisfactory.

关 键 词：西替利嗪 巴布剂 含水量 黏性 体外释放度 

分 类 号：R944.21[医药卫生—药剂学] R976[医药卫生—药学]