长春西汀的大鼠在体肠吸收研究  

Study on in situ Intestinal Absorption of Vinpocetine in Rats

作　　者：聂淑芳[1] 潘卫三[1] 李伟[1] 杜玍妮[1] 

机构地区：[1]沈阳药科大学药学系药剂教研室,辽宁沈阳110016

出　　处：《中国医药工业杂志》2005年第10期625-628,共4页Chinese Journal of Pharmaceuticals

摘　　要：采用单向灌流技术考察长春西汀的大鼠在体肠吸收性质。结果表明,灌流速度对药物吸收速率常数(Ka)和表观吸收系数(Papp)有极显著影响(P<0.01);药物浓度对Ka和Papp无显著影响(P>0.05);药物在全肠道吸收较好,吸收窗主要在小肠,且小肠内无明显的特定吸收部位;羟丙基-β-环糊精在1%～4%范围内对药物的肠吸收无显著影响。The in sire intestinal absorption property of vinpocetine in rats was investigated by means of single-pass intestinal perfusion technique. The results showed that perfusion flow rate could significantly affect the drug absorption constant （Ka） and apparent absorption coefficient （Papp） （P 〈 0.01）. Drug concentration had little effect on Ka and Papp （P 〉 0.05）. Vinpocetine could be absorbed well in general intestinal tract and especially in small intestine without specific absorption site. Vinpocetine in 1% to 4 % hydroxypropyl-a-cyclodextrin had no significant effect on drug absorption.

关 键 词：单向灌流法 长春西汀 在体肠吸收性质 

分 类 号：R972.4[医药卫生—药品] O657.63[医药卫生—药学]