大鼠肾X线衍射增强成像  

Diffraction enhanced imaging of rat kidney

作　　者：陈志华[1] 潘琳[1] 黎刚[2] 李红艳[1] 徐梅[1] 王自强[1] 朱佩平[2] 陈惟昌[1] 姜晓明[2] 吴自玉[2] 唐劲天[3] 

机构地区：[1]中日友好医院中日友好临床医学研究所,北京100029 [2]中国科学院高能物理研究所同步辐射室,北京100049 [3]清华大学工程物理系,北京100084

出　　处：《中国医学影像技术》2005年第9期1345-1348,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金重大项目(10490190)子课题(10490195);国家自然科学基金面上项目(10475090;60172042)资助。

摘　　要：目的探讨高衬度成像技术———同步辐射衍射增强成像(DEI)对肾脏成像的可能性。方法在北京同步辐射装置(BSRF)采用X线衍射增强成像法对离体的大鼠肾样品进行成像,成像样品的厚度分别为2mm和120μm。成像后的样品进行组织学切片,其结果和DEI结果进行对比分析。结果离体大鼠肾衍射增强成像可清晰显示常规成像方法无法观察到的走向清晰的髓质区直集合管和乳头管,以及常规需经造影处理才可见的小叶间动、静脉,最细可分辨直径为30μm的管道结构。结论同步辐射衍射增强成像法具有早期观察肾脏髓质病变及血管微细病变的潜力,该方法为目前影像学尚不能观察到的生物样品结构的成像提供了一种新的研究手段。Objective The purpose of this study was to explore the potential of diffraction enhanced imaging （DEI） of rat kidney. Methods The dissected kidney of rats with the thickness of 2 mm and 120 /μm were imaged with X-ray diffraction enhanced imaging at the Beijing Synchrotron Radiation Facility （BSRF）. Histological slides of the specimens were made after imaging and compared with the diffraction enhanced imaging of the specimens. Results The straight collecting ducts and pa- pillary tubules that can＇t be detected by conventional radiography are visible clearly down to approximately 30 /μm by DEI in dissected kidney of rats. The artery and vein that can only be detected through are visible clearly by DEI, too. Conclusion The results suggest that DEI with synchrotron X ray has the potential to be of use in the study of micro lesion of renal me dulla and vessel. This technique provides a new way of imaging the property of biological tissues not yet exploited.

关 键 词：X线 衍射增强成像 肾脏 

分 类 号：R814.4[医药卫生—影像医学与核医学] Q95-33[医药卫生—放射医学]