灯盏花素对脑缺血再灌注小鼠脑组织抗氧化酶的影响  

Effect of erigeron breviscapus on antioxidase during cerebral ischemia-reperfusion in mice

作　　者：朱丽娜[1] 卢晓梅[2] 赵成海[2] 王巍[2] 赵红[1] 

机构地区：[1]中国医科大学基础医学院机能中心,辽宁沈阳110001 [2]中国医科大学病理生理学教研室

出　　处：《中国医科大学学报》2005年第5期406-408,共3页Journal of China Medical University

摘　　要：目的:探讨灯盏花素注射液对脑缺血再灌注小鼠脑组织抗氧化酶的影响。方法:复制小鼠脑缺血再灌注模型,进行灯盏花素的治疗,监测不同时间脑皮质血流、脑组织Evans蓝含量及抗氧化酶类等的变化。结果:缺血再灌注后脑皮质血流降低,治疗后4 h升高,其他时间降低。不同再灌注时间脑缺血再灌注组脑组织Evans蓝含量升高,治疗后降低。脑缺血再灌注组抗氧化酶活性降低,MDA含量增高,而治疗组酶活性增高,MDA含量降低。结论:灯盏花素能增加脑缺血再灌注小鼠抗氧化酶的活性,改善脑血流,减轻血脑屏障的损伤,对脑缺血再灌注损伤具保护作用。Objective： To investigate the effect of erigeron breviscapus （EB） on the antioxidase during cerebral ischemia-reperfusion injury in mice. Methods： The injection of EB was repeated 7 times in mice model of cerebral ischemia-reperfusion injury in the EB-treated group. The cerebral blood flow and the contents of Evans blue and antioxidase in the brain tissue were determined at different times. Results： The cerebral blood flow in EB-treated group decreased after the ischemia-reperfusion injury, increased 4 hours after EB treatment, and then decreased. In the EB-treated group, the antioxidase activity increased, and tbe content of malondialodehyde decreased. Conclusion： EB may protect the brain from ischemia-reperfusion injury by increasing the activity of antioxidase, improving the cerebral blood flow, and alleviating the damage of blood-brain barrier.

关 键 词：灯盏花素 脑缺血再灌注 小鼠 抗氧化酶 

分 类 号：R965[医药卫生—药理学]