大鼠在体吸收连翘苷的机理研究  

The absorption mechanism of phillyrin in digestive tract in rat

作　　者：李芸霞[1] 蒋学华[1] 周静[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第5期387-390,共4页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(项目编号3007093530271614)

摘　　要：目的研究连翘苷在大鼠消化道内的吸收机理。方法采用HPLC测定大鼠在体实验中连翘苷的含量,分别进行大鼠原位胃吸收、结肠、小肠全肠段、分肠段(十二指肠、空肠、回肠)合用吸收促进剂(SDS、牛胆盐、冰片、卡波姆)的连翘苷吸收机理研究。结果连翘苷各时间点含量几乎不变。结论口服连翘苷在大鼠消化道内并无吸收。OBJECTIVE To explore the absorption characteristics and mechanism of phillyrin in digestive tract in rat. METHODS The concentration of phillyrin was determined by HPLC, and the absorption mechanism was investigated using in situ absorption in stomach and intestine in rat. RESULTS No change of phillyrin＇ s concentration in perfusion solution can be founded. CONCLUSION Phillynin can＇ t be absorbed in digestive tract in rat.

关 键 词：连翘苷 原位胃吸收 在体肠循环 

分 类 号：R969.1[医药卫生—药理学]