系数倍率法测定头液中水杨酸和苯酚的含量  

Determination of the contents of two ingredients in hair solution by K-ratio spectrophotometry

作　　者：王彦[1] 张碧玫[1] 

机构地区：[1]天津医科大学总医院,天津300052

出　　处：《华西药学杂志》2005年第5期442-444,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的测定头液中水杨酸和苯酚的含量.方法应用系数倍率紫外分光光度法,在298 nm和272 nm不经分离直接测定头液中两组份的含量.结果水杨酸在8～16 μg·ml-1范围内与吸光度的线性关系良好(r=0.9999),平均回收率为99.71%,RSD=0.48%(n=3);苯酚在4～8 μg·ml-1范围内与吸光度的线性关系良好(r=0.9998),平均回收率为99.33%,RSD=0.58%(n=3).结论方法简便、快速、准确,适用于该制剂的快速检验.OBJECTIVE To determine the contents of salicylic acid and phenol in hair solution, METHODS The concentrations of two in - gredients in the hair solution were directly determined at 272 nm and 298 nm by K - ratio spectrophotometry without separation. RESULTS Salicylic acid presented a good linear relation ship within a range of 8 - 16μg - ml^-1（ r = 0.9999）. The average recovery was 99.71%, with RSD of 0.48 % （ n = 3）, phenol presented a good linear ralation ship within a range of 4 - 8μg.ml^-1（ r = 0.9998）, The average recovery of phenol was 99.33 % with RSD of 0,58 % （n = 3）, CONCLUSION The method is simple, rapid and accurate, and suitable for rapid assay of the preparation.

关 键 词：系数倍率法 头液 水杨酸 苯酚 

分 类 号：R927.2[医药卫生—药学]